Component
Cob(II)alamin off-loading from human MMUT
Cob(II)alamin off-loading from human MMUT
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Under anaerobic conditions, ADP reduced the rate of cob(II)alamin transfer from human MMUT to MMAB in the MMAA repair system.
Experimental context and source evidence
- cross_nutrient
- false
- evidence_location
- Full text Results; Figures 2-3, Table 3
- experimental_model
- Purified human proteins
- exposure
- Anaerobic cofactor-transfer assay with ADP
- limitations
- Transfer rate differs from oxidation protection; methylmalonyl-CoA reversed ADP inhibition in this assay.
- nutrient_topic
- Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B12 (cobalamins)
- organism
- Homo sapiens
- plain_language
- When oxidation was excluded, ADP slowed transfer of inactive B12 between the purified human proteins.
- primary_references
- [gouda-2023-adp-repair] Bivalent molecular mimicry by ADP protects metal redox state and promotes coenzyme B12 repair. (2023). https://pubmed.ncbi.nlm.nih.gov/36888659/ DOI: 10.1073/pnas.2220677120
- tissue_or_cell_type
- Purified protein assay
Vitamin B12: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1412–1424
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified human proteins · source_derived_draft · unverified_draft
### adp-slows-mmut-cob-ii-offloading Under anaerobic conditions, ADP reduced the rate of cob(II)alamin transfer from human MMUT to MMAB in the MMAA repair system. Condition category: normal nutrient_topic: Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. plain_language: When oxidation was excluded, ADP slowed transfer of inactive B12 between the purified human proteins. organism: Homo sapiens tissue_or_cell_type: Purified protein assay experimental_model: Purified human proteins limitations: Transfer rate differs from oxidation protection; methylmalonyl-CoA reversed ADP inhibition in this assay. exposure: Anaerobic cofactor-transfer assay with ADP cross_nutrient: false evidence_location: Full text Results; Figures 2-3, Table 3 [gouda-2023-adp-repair] Bivalent molecular mimicry by ADP protects metal redox state and promotes coenzyme B12 repair. (2023). https://pubmed.ncbi.nlm.nih.gov/36888659/ DOI: 10.1073/pnas.2220677120
Complete structured claim and evidenceA human MMAA/MMAB repair mixture with GTP and ATP transferred cob(II)alamin from MMUT to MMAB in anaerobic spectroscopy.
Experimental context and source evidence
- cross_nutrient
- false
- evidence_location
- Full text Results; Figures 2-4; cofactor off-loading and MMUT activity Methods
- experimental_model
- Purified human proteins
- exposure
- Anaerobic assay; MMAB, MMAA, GTP and ATP
- limitations
- Reconstituted transfer; spectroscopy reports cofactor environment, not cellular turnover.
- nutrient_topic
- Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B12 (cobalamins)
- organism
- Homo sapiens
- plain_language
- In the purified repair assay, inactive B12 moved from MMUT back to MMAB.
- primary_references
- [mascarenhas-2023-nanoassembly] Architecture of the human G-protein-methylmalonyl-CoA mutase nanoassembly for B12 delivery and repair. (2023). https://pubmed.ncbi.nlm.nih.gov/37468522/ DOI: 10.1038/s41467-023-40077-4
- tissue_or_cell_type
- Purified protein assay
Vitamin B12: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1131–1143
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified human proteins · source_derived_draft · unverified_draft
### mmaa-mmab-offload-cob-ii A human MMAA/MMAB repair mixture with GTP and ATP transferred cob(II)alamin from MMUT to MMAB in anaerobic spectroscopy. Condition category: normal nutrient_topic: Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. plain_language: In the purified repair assay, inactive B12 moved from MMUT back to MMAB. organism: Homo sapiens tissue_or_cell_type: Purified protein assay experimental_model: Purified human proteins limitations: Reconstituted transfer; spectroscopy reports cofactor environment, not cellular turnover. exposure: Anaerobic assay; MMAB, MMAA, GTP and ATP cross_nutrient: false evidence_location: Full text Results; Figures 2-4; cofactor off-loading and MMUT activity Methods [mascarenhas-2023-nanoassembly] Architecture of the human G-protein-methylmalonyl-CoA mutase nanoassembly for B12 delivery and repair. (2023). https://pubmed.ncbi.nlm.nih.gov/37468522/ DOI: 10.1038/s41467-023-40077-4
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.