Component
Human MMAB p.Arg186Gln
Human MMAB p.Arg186Gln
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
R186Q human MMAB showed no detectable adenosylcobalamin synthesis with FDX1/FDXR/NADPH, although a strong chemical reductant supported activity.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- true
- evidence_location
- Abstract and indexed primary Results, Figure 3
- experimental_model
- Purified human MMAB R186Q
- exposure
- R186Q variant; FDX1/FDXR/NADPH versus titanium(III)citrate
- limitations
- Detection-limited in-vitro activity; not proof of zero activity in every tissue.
- nutrient_topic
- Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B12 (cobalamins)
- organism
- Homo sapiens
- plain_language
- This MMAB variant failed in the ferredoxin assay; the result depended on the electron donor.
- primary_references
- [gouda-2023-mmab-redox] Coordination Chemistry Controls Coenzyme B12 Synthesis by Human Adenosine Triphosphate:Cob(I)alamin Adenosyltransferase. (2023). https://pubmed.ncbi.nlm.nih.gov/37526260/ DOI: 10.1021/acs.inorgchem.3c02163
- tissue_or_cell_type
- Purified protein assay
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin B12: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1019–1031
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified human MMAB R186Q · source_derived_draft · unverified_draft
### mmab-r186q-fdx-system-fails R186Q human MMAB showed no detectable adenosylcobalamin synthesis with FDX1/FDXR/NADPH, although a strong chemical reductant supported activity. Condition category: machinery_impairment nutrient_topic: Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. plain_language: This MMAB variant failed in the ferredoxin assay; the result depended on the electron donor. organism: Homo sapiens tissue_or_cell_type: Purified protein assay experimental_model: Purified human MMAB R186Q limitations: Detection-limited in-vitro activity; not proof of zero activity in every tissue. exposure: R186Q variant; FDX1/FDXR/NADPH versus titanium(III)citrate cross_nutrient: true evidence_location: Abstract and indexed primary Results, Figure 3 [gouda-2023-mmab-redox] Coordination Chemistry Controls Coenzyme B12 Synthesis by Human Adenosine Triphosphate:Cob(I)alamin Adenosyltransferase. (2023). https://pubmed.ncbi.nlm.nih.gov/37526260/ DOI: 10.1021/acs.inorgchem.3c02163
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.