Component
Human MMAA p.Gly188Arg
Human MMAA p.Gly188Arg
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Human MMAA G188R retained basal GTPase activity but lost the detected MMUT interaction.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- evidence_location
- Indexed primary abstract; indexed Results
- experimental_model
- Human MMAA G188R functional assays
- exposure
- G188R patient variant versus wild type
- limitations
- Interaction defect in experimental assays; residual tissue-specific function was not quantified.
- nutrient_topic
- Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B12 (cobalamins)
- organism
- Homo sapiens
- plain_language
- In the human-protein experiment, this MMAA variant still hydrolyzed GTP but failed to bind MMUT normally.
- primary_references
- [froese-2010-human-mmaa] Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation. (2010). https://pubmed.ncbi.nlm.nih.gov/20876572/ DOI: 10.1074/jbc.m110.177717
- tissue_or_cell_type
- Purified protein assay
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin B12: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1061–1073
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human MMAA G188R functional assays · source_derived_draft · unverified_draft
### mmaa-g188r-loses-mmut-interaction Human MMAA G188R retained basal GTPase activity but lost the detected MMUT interaction. Condition category: machinery_impairment nutrient_topic: Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. plain_language: In the human-protein experiment, this MMAA variant still hydrolyzed GTP but failed to bind MMUT normally. organism: Homo sapiens tissue_or_cell_type: Purified protein assay experimental_model: Human MMAA G188R functional assays limitations: Interaction defect in experimental assays; residual tissue-specific function was not quantified. exposure: G188R patient variant versus wild type cross_nutrient: false evidence_location: Indexed primary abstract; indexed Results [froese-2010-human-mmaa] Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation. (2010). https://pubmed.ncbi.nlm.nih.gov/20876572/ DOI: 10.1074/jbc.m110.177717
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.