Component
Serum menaquinone-4 concentration
Serum menaquinone-4 concentration. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
MK-4 was not detected in serum after the tested 420-microgram dose and serum MK-4 did not increase with the seven-day 60-microgram regimen.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/k2-research/23140417.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e72bb9c0cc5800cba0605d7abba2c4e6c113dda5fa0e9b4a3afff898b23a97c4", "start_char": 0, "end_char": 1328, "text_sha256": "e72bb9c0cc5800cba0605d7abba2c4e6c113dda5fa0e9b4a3afff898b23a97c4"}
- experimental_model
- Single-dose and seven-day nutritional-dose comparison
- exposure
- 420 micrograms single dose or 60 micrograms/day for seven days; MK-4 versus MK-7
- limitations
- Small parallel groups; equal mass is not equal molar dose. Undetectable serum MK-4 does not prove absent absorption, absent tissue delivery or clinical ineffectiveness.
- nutrient_topic
- Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
- organism
- Healthy young Japanese women
- plain_language
- The blood test behaved differently for MK-4; that does not tell us that none reached tissues.
- primary_references
- [k2-p23140417] Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women. (2012). https://pubmed.ncbi.nlm.nih.gov/23140417/ DOI: 10.1186/1475-2891-11-93
- tissue_or_cell_type
- Serum vitamin K concentrations
Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 279–290
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Single-dose and seven-day nutritional-dose comparison · source_derived_draft · unverified_draft
### k2-mk4-serum MK-4 was not detected in serum after the tested 420-microgram dose and serum MK-4 did not increase with the seven-day 60-microgram regimen. Condition category: normal nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The blood test behaved differently for MK-4; that does not tell us that none reached tissues. organism: Healthy young Japanese women tissue_or_cell_type: Serum vitamin K concentrations experimental_model: Single-dose and seven-day nutritional-dose comparison limitations: Small parallel groups; equal mass is not equal molar dose. Undetectable serum MK-4 does not prove absent absorption, absent tissue delivery or clinical ineffectiveness. exposure: 420 micrograms single dose or 60 micrograms/day for seven days; MK-4 versus MK-7 evidence_span: {"source_cache": "artifacts/k2-research/23140417.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e72bb9c0cc5800cba0605d7abba2c4e6c113dda5fa0e9b4a3afff898b23a97c4", "start_char": 0, "end_char": 1328, "text_sha256": "e72bb9c0cc5800cba0605d7abba2c4e6c113dda5fa0e9b4a3afff898b23a97c4"} [k2-p23140417] Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women. (2012). https://pubmed.ncbi.nlm.nih.gov/23140417/ DOI: 10.1186/1475-2891-11-93
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.