Component
Mitochondrial respiratory enzyme activities
Mitochondrial respiratory enzyme activities. Experimental scope belongs to each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Patient 1 had low liver complex IV and II+III activities, elevated complex I, borderline-low muscle complex IV and reduced pyruvate dehydrogenase activity.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- Human ZIP8 (SLC39A8) (affected_protein)
- evidence_span
- {"source_cache": "artifacts/manganese-clinical-sources/riley2017.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "31e4e33ec5601d443fb2d469b2e2c7d1fd89c611db0f41938b43007952d0f005", "start_char": 0, "end_char": 1732, "text_sha256": "31e4e33ec5601d443fb2d469b2e2c7d1fd89c611db0f41938b43007952d0f005", "text_characters": 1732}
- experimental_model
- Two sisters with homozygous SLC39A8 p.Cys113Ser
- exposure
- Respiratory-chain tests in patient 1; manganese and transferrin measurements and galactose-plus-uridine response in patient 2.
- limitations
- Measurements were not performed in both sisters interchangeably. The proposed SOD2 explanation was not directly demonstrated; manganese had only recently been added and cannot explain the already observed 14-day galactose/uridine response.
- nutrient_topic
- Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
- organism
- Homo sapiens
- plain_language
- The affected child had several mitochondrial enzyme abnormalities, without proof that each enzyme directly requires manganese.
- primary_references
- [mn-clin-riley2017] A SLC39A8 variant causes manganese deficiency, and glycosylation and mitochondrial disorders. (2017). https://pubmed.ncbi.nlm.nih.gov/27995398/ DOI: 10.1007/s10545-016-0010-6
- tissue_or_cell_type
- Patient-specific liver, muscle and blood measurements
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 1216–1228
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Two sisters with homozygous SLC39A8 p.Cys113Ser · source_derived_draft · unverified_draft
### mn-clin-zip8-respiratory-chain Patient 1 had low liver complex IV and II+III activities, elevated complex I, borderline-low muscle complex IV and reduced pyruvate dehydrogenase activity. Condition category: machinery_impairment nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: The affected child had several mitochondrial enzyme abnormalities, without proof that each enzyme directly requires manganese. organism: Homo sapiens tissue_or_cell_type: Patient-specific liver, muscle and blood measurements experimental_model: Two sisters with homozygous SLC39A8 p.Cys113Ser limitations: Measurements were not performed in both sisters interchangeably. The proposed SOD2 explanation was not directly demonstrated; manganese had only recently been added and cannot explain the already observed 14-day galactose/uridine response. exposure: Respiratory-chain tests in patient 1; manganese and transferrin measurements and galactose-plus-uridine response in patient 2. cross_nutrient: Human ZIP8 (SLC39A8) (affected_protein) evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/riley2017.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "31e4e33ec5601d443fb2d469b2e2c7d1fd89c611db0f41938b43007952d0f005", "start_char": 0, "end_char": 1732, "text_sha256": "31e4e33ec5601d443fb2d469b2e2c7d1fd89c611db0f41938b43007952d0f005", "text_characters": 1732} [mn-clin-riley2017] A SLC39A8 variant causes manganese deficiency, and glycosylation and mitochondrial disorders. (2017). https://pubmed.ncbi.nlm.nih.gov/27995398/ DOI: 10.1007/s10545-016-0010-6
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.