Component
Mitochondrial folate uptake
Uptake of folate substrates by isolated mitochondria.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Slc25a32 mutant and knockout mitochondrial preparations retained folate-substrate uptake in the 2022 mouse study.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- Separates primary flavin import from secondary folate-pool changes.
- evidence_location
- Abstract and folate-uptake experiments
- experimental_model
- Folate uptake in genetically altered isolated mitochondria
- exposure
- Labeled folic acid or 5-formyltetrahydrofolate in mitochondrial uptake assays.
- limitations
- Preserved uptake in this model does not fully resolve older human-cDNA complementation results.
- nutrient_topic
- Riboflavin research collection; topical membership is not evidence of a direct dietary effect. · Riboflavin (vitamin B2)
- organism
- Mus musculus
- plain_language
- The mouse experiments attributed the primary import defect to FAD, with folate uptake preserved.
- primary_references
- [transport-slc25a32-2022] Mitochondrial FAD shortage in SLC25A32 deficiency affects folate-mediated one-carbon metabolism. (2022). https://pmc.ncbi.nlm.nih.gov/articles/PMC11072207/ DOI: 10.1007/s00018-022-04404-0
- tissue_or_cell_type
- Muscle and embryonic mitochondria
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Riboflavin: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 516–528
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Folate uptake in genetically altered isolated mitochondria · source_derived_draft · unverified_draft
### transport-slc25a32-folate-uptake-preserved Slc25a32 mutant and knockout mitochondrial preparations retained folate-substrate uptake in the 2022 mouse study. Condition category: machinery_impairment nutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The mouse experiments attributed the primary import defect to FAD, with folate uptake preserved. organism: Mus musculus tissue_or_cell_type: Muscle and embryonic mitochondria experimental_model: Folate uptake in genetically altered isolated mitochondria limitations: Preserved uptake in this model does not fully resolve older human-cDNA complementation results. exposure: Labeled folic acid or 5-formyltetrahydrofolate in mitochondrial uptake assays. cross_nutrient: Separates primary flavin import from secondary folate-pool changes. evidence_location: Abstract and folate-uptake experiments [transport-slc25a32-2022] Mitochondrial FAD shortage in SLC25A32 deficiency affects folate-mediated one-carbon metabolism. (2022). https://pmc.ncbi.nlm.nih.gov/articles/PMC11072207/ DOI: 10.1007/s00018-022-04404-0
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.