Component
Milk manganese normalized to protein
Milk manganese normalized to protein. Experimental scope belongs to each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
After normalization to milk protein, calcium and manganese were lower in milk from Tmem165-deficient dams.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- Mouse TMEM165 (affected_protein); Milk calcium normalized to protein (measured_endpoint); Calcium (affected_nutrient); Manganese (affected_nutrient)
- evidence_span
- {"source_cache": "artifacts/manganese-glycosylation-sources/milk2019.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "88bcb50ecdb918803c5950bcff8f48665dbd17148b365a4f9f3b463fe7edd2a4", "start_char": 0, "end_char": 1462, "text_sha256": "88bcb50ecdb918803c5950bcff8f48665dbd17148b365a4f9f3b463fe7edd2a4", "text_characters": 1462}
- experimental_model
- Conditional mammary epithelial Tmem165 deletion in mice
- exposure
- Tissue-specific deletion with milk composition and pup-growth measurements.
- limitations
- The primary abstract supports normalized milk minerals and reduced lactose; altered concentration can reflect less milk dilution. Proposed cation/H+ exchange is an interpretation, not a transport stoichiometry measured here.
- nutrient_topic
- Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
- organism
- Mus musculus
- plain_language
- The defect changed milk manganese and calcium relative to its protein content.
- primary_references
- [mn-gly-milk2019] Milk biosynthesis requires the Golgi cation exchanger TMEM165. (2019). https://pubmed.ncbi.nlm.nih.gov/30622138/ DOI: 10.1074/jbc.ra118.006270
- tissue_or_cell_type
- Lactating mammary gland and milk
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 894–906
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Conditional mammary epithelial Tmem165 deletion in mice · source_derived_draft · unverified_draft
### mn-gly-mammary-minerals After normalization to milk protein, calcium and manganese were lower in milk from Tmem165-deficient dams. Condition category: machinery_impairment nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: The defect changed milk manganese and calcium relative to its protein content. organism: Mus musculus tissue_or_cell_type: Lactating mammary gland and milk experimental_model: Conditional mammary epithelial Tmem165 deletion in mice limitations: The primary abstract supports normalized milk minerals and reduced lactose; altered concentration can reflect less milk dilution. Proposed cation/H+ exchange is an interpretation, not a transport stoichiometry measured here. exposure: Tissue-specific deletion with milk composition and pup-growth measurements. cross_nutrient: Mouse TMEM165 (affected_protein); Milk calcium normalized to protein (measured_endpoint); Calcium (affected_nutrient); Manganese (affected_nutrient) evidence_span: {"source_cache": "artifacts/manganese-glycosylation-sources/milk2019.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "88bcb50ecdb918803c5950bcff8f48665dbd17148b365a4f9f3b463fe7edd2a4", "start_char": 0, "end_char": 1462, "text_sha256": "88bcb50ecdb918803c5950bcff8f48665dbd17148b365a4f9f3b463fe7edd2a4", "text_characters": 1462} [mn-gly-milk2019] Milk biosynthesis requires the Golgi cation exchanger TMEM165. (2019). https://pubmed.ncbi.nlm.nih.gov/30622138/ DOI: 10.1074/jbc.ra118.006270
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.