Plasma midazolam exposure: molecular mechanisms & dependencies

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

No meaningful overall midazolam pharmacokinetic change was found.
Curcuminoid-piperine preparation, study-specific → Plasma midazolam exposure source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/curcumin-research/22725836.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "255db8a54957c442fe6fca1d21aafe393e3a5506bec7330b49e1bb6f85d86127", "start_char": 0, "end_char": 1977, "text_sha256": "255db8a54957c442fe6fca1d21aafe393e3a5506bec7330b49e1bb6f85d86127"}
experimental_model
Randomized six-way crossover in eight healthy volunteers
exposure
4 g curcuminoids plus 24 mg piperine, four doses over two days before each probe drug
limitations
Short regimen and small sample. A null result for these probes does not establish no interactions with all medicines or preparations.
nutrient_topic
Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
organism
Homo sapiens
plain_language
The CYP3A probe did not show the expected major exposure change.
primary_references
[curcumin-p22725836] Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers. (2013). https://pubmed.ncbi.nlm.nih.gov/22725836/ DOI: 10.1111/j.1365-2125.2012.04364.x
tissue_or_cell_type
Drug pharmacokinetics
Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 918–929
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized six-way crossover in eight healthy volunteers · source_derived_draft · unverified_draft
### curcumin-midazolam-null No meaningful overall midazolam pharmacokinetic change was found. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The CYP3A probe did not show the expected major exposure change. organism: Homo sapiens tissue_or_cell_type: Drug pharmacokinetics experimental_model: Randomized six-way crossover in eight healthy volunteers limitations: Short regimen and small sample. A null result for these probes does not establish no interactions with all medicines or preparations. exposure: 4 g curcuminoids plus 24 mg piperine, four doses over two days before each probe drug evidence_span: {"source_cache": "artifacts/curcumin-research/22725836.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "255db8a54957c442fe6fca1d21aafe393e3a5506bec7330b49e1bb6f85d86127", "start_char": 0, "end_char": 1977, "text_sha256": "255db8a54957c442fe6fca1d21aafe393e3a5506bec7330b49e1bb6f85d86127"} [curcumin-p22725836] Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers. (2013). https://pubmed.ncbi.nlm.nih.gov/22725836/ DOI: 10.1111/j.1365-2125.2012.04364.x
Complete structured claim and evidence
Midazolam AUC to infinity increased approximately 40% and Cmax 38% after repeated berberine.
Berberine → Plasma midazolam exposure source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/berberine-research/21870106.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "12e465c3c0a8ce995697a6fb9bf77c079e38b413e82c8b4f2a82e45a3dbf8ae5", "start_char": 0, "end_char": 1817, "text_sha256": "12e465c3c0a8ce995697a6fb9bf77c079e38b413e82c8b4f2a82e45a3dbf8ae5"}
experimental_model
Two-phase randomized crossover enzyme-phenotyping study
exposure
Berberine 300 mg three times daily for 14 days versus placebo
limitations
Small short-term study. Probe metabolic ratios are not percentage inhibition of every substrate. No universal dose-adjustment rule; no statistically significant effect is not equivalence.
nutrient_topic
Berberine research collection; topical membership is not evidence of a direct dietary effect. · Berberine
organism
Healthy human male volunteers; 17 completed
plain_language
One actual medicine had greater systemic exposure in this controlled study.
primary_references
[berberine-p21870106] Repeated administration of berberine inhibits cytochromes P450 in humans. (2012). https://pubmed.ncbi.nlm.nih.gov/21870106/ DOI: 10.1007/s00228-011-1108-2
tissue_or_cell_type
Oral probe pharmacokinetics and urinary metabolite ratios
Berberine: metabolism, nutrient connections and drug interactions (2026-09-17) · lines 701–712
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Two-phase randomized crossover enzyme-phenotyping study · source_derived_draft · unverified_draft
### berberine-midazolam-auc Midazolam AUC to infinity increased approximately 40% and Cmax 38% after repeated berberine. Condition category: normal nutrient_topic: Berberine research collection; topical membership is not evidence of a direct dietary effect. plain_language: One actual medicine had greater systemic exposure in this controlled study. organism: Healthy human male volunteers; 17 completed tissue_or_cell_type: Oral probe pharmacokinetics and urinary metabolite ratios experimental_model: Two-phase randomized crossover enzyme-phenotyping study limitations: Small short-term study. Probe metabolic ratios are not percentage inhibition of every substrate. No universal dose-adjustment rule; no statistically significant effect is not equivalence. exposure: Berberine 300 mg three times daily for 14 days versus placebo evidence_span: {"source_cache": "artifacts/berberine-research/21870106.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "12e465c3c0a8ce995697a6fb9bf77c079e38b413e82c8b4f2a82e45a3dbf8ae5", "start_char": 0, "end_char": 1817, "text_sha256": "12e465c3c0a8ce995697a6fb9bf77c079e38b413e82c8b4f2a82e45a3dbf8ae5"} [berberine-p21870106] Repeated administration of berberine inhibits cytochromes P450 in humans. (2012). https://pubmed.ncbi.nlm.nih.gov/21870106/ DOI: 10.1007/s00228-011-1108-2
Complete structured claim and evidence

The events it takes part in

A mechanism often involves more than two components. These are the full events, with every participant and its role.

Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

Open hypotheses

Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.

This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

Plasma midazolam exposure