Component
Mesenteric vascular resistance
Mesenteric vascular resistance. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Indomethacin produced severe acute mesenteric vasoconstriction by intravenous infusion and by intra-arterial injection with rapid tachyphylaxis, whereas ibuprofen did not alter mesenteric blood flow even when a large 50 milligram bolus was rapidly injected, and the indomethacin response was not modified when prostaglandin synthesis was inhibited nor significantly mediated by alpha adrenergic agents or serotonin, while both drugs raised aortic pressure and reduced renal blood flow by small but significant amounts.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/ibuprofen-research/7299691.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "217a7f084ce5301b9b357bed0af13552ba7114c56c9d2692852bd4581450a02d", "start_char": 0, "end_char": 1542, "text_sha256": "217a7f084ce5301b9b357bed0af13552ba7114c56c9d2692852bd4581450a02d"}
- experimental_model
- Regional vascular resistance measurement in pentobarbital-anaesthetised dogs
- exposure
- Indomethacin and ibuprofen given intravenously and intra-arterially, including a 50 milligram intravenous bolus
- limitations
- A direct head-to-head between two drugs of the same class in the same animals, with a negative result for ibuprofen. Anaesthetised dogs.
- nutrient_topic
- Ibuprofen research collection; topical membership is not evidence of a direct clinical effect, and the racemate is recorded separately from each of its two enantiomers. · Ibuprofen
- organism
- Dog
- plain_language
- One drug of this class strangles the gut circulation and the other does not, and it is not a prostaglandin effect.
- primary_references
- [ibu-p7299691] Differential effects of ibuprofen and indomethacin in the regional circulation of the dog. (1981). https://pubmed.ncbi.nlm.nih.gov/7299691/ DOI: 10.1016/s0022-3565(25)32861-2
- tissue_or_cell_type
- Mesenteric and renal circulations
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Regional vascular resistance measurement in pentobarbital-anaesthetised dogs · source_derived_draft · unverified_draft
### ibu-not-a-class-effect Indomethacin produced severe acute mesenteric vasoconstriction by intravenous infusion and by intra-arterial injection with rapid tachyphylaxis, whereas ibuprofen did not alter mesenteric blood flow even when a large 50 milligram bolus was rapidly injected, and the indomethacin response was not modified when prostaglandin synthesis was inhibited nor significantly mediated by alpha adrenergic agents or serotonin, while both drugs raised aortic pressure and reduced renal blood flow by small but significant amounts. Condition category: normal nutrient_topic: Ibuprofen research collection; topical membership is not evidence of a direct clinical effect, and the racemate is recorded separately from each of its two enantiomers. plain_language: One drug of this class strangles the gut circulation and the other does not, and it is not a prostaglandin effect. organism: Dog tissue_or_cell_type: Mesenteric and renal circulations experimental_model: Regional vascular resistance measurement in pentobarbital-anaesthetised dogs limitations: A direct head-to-head between two drugs of the same class in the same animals, with a negative result for ibuprofen. Anaesthetised dogs. exposure: Indomethacin and ibuprofen given intravenously and intra-arterially, including a 50 milligram intravenous bolus evidence_span: {"source_cache": "artifacts/ibuprofen-research/7299691.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "217a7f084ce5301b9b357bed0af13552ba7114c56c9d2692852bd4581450a02d", "start_char": 0, "end_char": 1542, "text_sha256": "217a7f084ce5301b9b357bed0af13552ba7114c56c9d2692852bd4581450a02d"} [ibu-p7299691] Differential effects of ibuprofen and indomethacin in the regional circulation of the dog. (1981). https://pubmed.ncbi.nlm.nih.gov/7299691/ DOI: 10.1016/s0022-3565(25)32861-2
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.