Component
Menadiol / reduced menadione
Menadiol / reduced menadione. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Product analysis identified reduced menadione, rather than its quinone form, as an intermediate in UBIAD1-mediated MK-4 formation.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/k2-research/24085302.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a0197882d517aa2bd4d9b2919e72c588383ad183064f1a2bf8f64f5152d28386", "start_char": 0, "end_char": 1653, "text_sha256": "a0197882d517aa2bd4d9b2919e72c588383ad183064f1a2bf8f64f5152d28386"}
- experimental_model
- Stable-isotope cannulation and recombinant-enzyme product analysis
- exposure
- Oral labeled phylloquinone; MS and NMR analysis
- limitations
- Rat tracing defines a precursor route; no exact human conversion fraction or advice to ingest menadione is inferred.
- nutrient_topic
- Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
- organism
- Rats and recombinant UBIAD1
- plain_language
- The precursor must also be in the right redox state.
- primary_references
- [k2-p24085302] Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats. (2013). https://pubmed.ncbi.nlm.nih.gov/24085302/ DOI: 10.1074/jbc.m113.477356
- tissue_or_cell_type
- Intestine, circulation and tissue synthesis
Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 188–199
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Stable-isotope cannulation and recombinant-enzyme product analysis · source_derived_draft · unverified_draft
### k2-reduced-precursor Product analysis identified reduced menadione, rather than its quinone form, as an intermediate in UBIAD1-mediated MK-4 formation. Condition category: normal nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The precursor must also be in the right redox state. organism: Rats and recombinant UBIAD1 tissue_or_cell_type: Intestine, circulation and tissue synthesis experimental_model: Stable-isotope cannulation and recombinant-enzyme product analysis limitations: Rat tracing defines a precursor route; no exact human conversion fraction or advice to ingest menadione is inferred. exposure: Oral labeled phylloquinone; MS and NMR analysis evidence_span: {"source_cache": "artifacts/k2-research/24085302.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a0197882d517aa2bd4d9b2919e72c588383ad183064f1a2bf8f64f5152d28386", "start_char": 0, "end_char": 1653, "text_sha256": "a0197882d517aa2bd4d9b2919e72c588383ad183064f1a2bf8f64f5152d28386"} [k2-p24085302] Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats. (2013). https://pubmed.ncbi.nlm.nih.gov/24085302/ DOI: 10.1074/jbc.m113.477356
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.