Component
Amplitude of endogenous melatonin rhythm
Amplitude of endogenous melatonin rhythm. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Melatonin rhythm amplitude before the light exposure was smaller during the B12 condition.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/melatonin-research/8981490.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d0079778f8efe44c1538b9c85d56b12a3a766b734aab19660419fd461ec22792", "start_char": 0, "end_char": 895, "text_sha256": "d0079778f8efe44c1538b9c85d56b12a3a766b734aab19660419fd461ec22792"}
- experimental_model
- Single-blind crossover light-response experiment
- exposure
- Methylcobalamin IV 0.5 mg/day for 11 days then oral 6 mg/day for seven; morning 2500-lux light for three hours
- limitations
- Small pharmacological B12 study, not B12-deficient participants. Does not establish a routine sleep treatment or increased melatonin production.
- nutrient_topic
- Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
- organism
- Eight young men
- plain_language
- A lower amplitude and a shifted clock are separate measurements.
- primary_references
- [melatonin-p8981490] Vitamin B12 enhances the phase-response of circadian melatonin rhythm to a single bright light exposure in humans. (1996). https://pubmed.ncbi.nlm.nih.gov/8981490/ DOI: 10.1016/s0304-3940(96)13247-x
- tissue_or_cell_type
- Circadian melatonin rhythm
Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 812–823
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Single-blind crossover light-response experiment · source_derived_draft · unverified_draft
### melatonin-b12-amplitude Melatonin rhythm amplitude before the light exposure was smaller during the B12 condition. Condition category: normal nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A lower amplitude and a shifted clock are separate measurements. organism: Eight young men tissue_or_cell_type: Circadian melatonin rhythm experimental_model: Single-blind crossover light-response experiment limitations: Small pharmacological B12 study, not B12-deficient participants. Does not establish a routine sleep treatment or increased melatonin production. exposure: Methylcobalamin IV 0.5 mg/day for 11 days then oral 6 mg/day for seven; morning 2500-lux light for three hours evidence_span: {"source_cache": "artifacts/melatonin-research/8981490.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d0079778f8efe44c1538b9c85d56b12a3a766b734aab19660419fd461ec22792", "start_char": 0, "end_char": 895, "text_sha256": "d0079778f8efe44c1538b9c85d56b12a3a766b734aab19660419fd461ec22792"} [melatonin-p8981490] Vitamin B12 enhances the phase-response of circadian melatonin rhythm to a single bright light exposure in humans. (1996). https://pubmed.ncbi.nlm.nih.gov/8981490/ DOI: 10.1016/s0304-3940(96)13247-x
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.