Component
Absolute oral melatonin bioavailability
Absolute oral melatonin bioavailability. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Median absolute oral bioavailability was 2.5% in the 10 mg crossover study.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/melatonin-research/26893170.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "adf51f044cbe9fe89a19af5452dbf050dc60d611a590bc2544aed1c39ff4571c", "start_char": 0, "end_char": 1763, "text_sha256": "adf51f044cbe9fe89a19af5452dbf050dc60d611a590bc2544aed1c39ff4571c"}
- experimental_model
- Oral versus intravenous crossover pharmacokinetics
- exposure
- 10 mg oral and 10 mg intravenous on separate days
- limitations
- Specific immediate-release preparation and study population. Bioavailability varies by formulation and individual; not a dosing recommendation.
- nutrient_topic
- Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
- organism
- Twelve healthy men
- plain_language
- The swallowed amount and the amount reaching circulation are very different quantities.
- primary_references
- [melatonin-p26893170] Pharmacokinetics of oral and intravenous melatonin in healthy volunteers. (2016). https://pubmed.ncbi.nlm.nih.gov/26893170/ DOI: 10.1186/s40360-016-0052-2
- tissue_or_cell_type
- Plasma exposure
Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 656–667
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Oral versus intravenous crossover pharmacokinetics · source_derived_draft · unverified_draft
### melatonin-oral-bioavailability Median absolute oral bioavailability was 2.5% in the 10 mg crossover study. Condition category: normal nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The swallowed amount and the amount reaching circulation are very different quantities. organism: Twelve healthy men tissue_or_cell_type: Plasma exposure experimental_model: Oral versus intravenous crossover pharmacokinetics limitations: Specific immediate-release preparation and study population. Bioavailability varies by formulation and individual; not a dosing recommendation. exposure: 10 mg oral and 10 mg intravenous on separate days evidence_span: {"source_cache": "artifacts/melatonin-research/26893170.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "adf51f044cbe9fe89a19af5452dbf050dc60d611a590bc2544aed1c39ff4571c", "start_char": 0, "end_char": 1763, "text_sha256": "adf51f044cbe9fe89a19af5452dbf050dc60d611a590bc2544aed1c39ff4571c"} [melatonin-p26893170] Pharmacokinetics of oral and intravenous melatonin in healthy volunteers. (2016). https://pubmed.ncbi.nlm.nih.gov/26893170/ DOI: 10.1186/s40360-016-0052-2
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.