Component

Phase of the endogenous melatonin circadian rhythm

Phase of the endogenous melatonin circadian rhythm. Species, exposure and limitations are retained in each linked claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. The phase-advance response peaked about five hours before dim-light melatonin onset in the three-pulse experiment.

    Melatonin → Phase of the endogenous melatonin circadian rhythm source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/melatonin-research/18006583.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9eb1409f6e4c58eadfaf1554930378e03860dc9dc1201de6d104b6de784758ea", "start_char": 0, "end_char": 1518, "text_sha256": "9eb1409f6e4c58eadfaf1554930378e03860dc9dc1201de6d104b6de784758ea"}
    experimental_model
    Double-blind counterbalanced phase-response experiment
    exposure
    3 mg once daily for three days at different circadian times; dim-light onset measured
    limitations
    Timing is relative to individual biological phase, not a universal clock hour. This experimental schedule is not a dosing instruction.
    nutrient_topic
    Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
    organism
    27 healthy young adults
    plain_language
    The same hormone can move the body clock earlier when given at the appropriate biological time.
    primary_references
    [melatonin-p18006583] A three pulse phase response curve to three milligrams of melatonin in humans. (2008). https://pubmed.ncbi.nlm.nih.gov/18006583/ DOI: 10.1113/jphysiol.2007.143180
    tissue_or_cell_type
    Circadian melatonin timing

    Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 838–849

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind counterbalanced phase-response experiment · source_derived_draft · unverified_draft

    ### melatonin-phase-advance The phase-advance response peaked about five hours before dim-light melatonin onset in the three-pulse experiment. Condition category: normal nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The same hormone can move the body clock earlier when given at the appropriate biological time. organism: 27 healthy young adults tissue_or_cell_type: Circadian melatonin timing experimental_model: Double-blind counterbalanced phase-response experiment limitations: Timing is relative to individual biological phase, not a universal clock hour. This experimental schedule is not a dosing instruction. exposure: 3 mg once daily for three days at different circadian times; dim-light onset measured evidence_span: {"source_cache": "artifacts/melatonin-research/18006583.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9eb1409f6e4c58eadfaf1554930378e03860dc9dc1201de6d104b6de784758ea", "start_char": 0, "end_char": 1518, "text_sha256": "9eb1409f6e4c58eadfaf1554930378e03860dc9dc1201de6d104b6de784758ea"} [melatonin-p18006583] A three pulse phase response curve to three milligrams of melatonin in humans. (2008). https://pubmed.ncbi.nlm.nih.gov/18006583/ DOI: 10.1113/jphysiol.2007.143180
    Complete structured claim and evidence

  2. The first half of habitual sleep corresponded to a region of minimal phase shifts in this protocol.

    Melatonin → Phase of the endogenous melatonin circadian rhythm source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/melatonin-research/18006583.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9eb1409f6e4c58eadfaf1554930378e03860dc9dc1201de6d104b6de784758ea", "start_char": 0, "end_char": 1518, "text_sha256": "9eb1409f6e4c58eadfaf1554930378e03860dc9dc1201de6d104b6de784758ea"}
    experimental_model
    Double-blind counterbalanced phase-response experiment
    exposure
    3 mg once daily for three days at different circadian times; dim-light onset measured
    limitations
    Timing is relative to individual biological phase, not a universal clock hour. This experimental schedule is not a dosing instruction.
    nutrient_topic
    Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
    organism
    27 healthy young adults
    plain_language
    A sleep-promoting effect is not identical to resetting the clock.
    primary_references
    [melatonin-p18006583] A three pulse phase response curve to three milligrams of melatonin in humans. (2008). https://pubmed.ncbi.nlm.nih.gov/18006583/ DOI: 10.1113/jphysiol.2007.143180
    tissue_or_cell_type
    Circadian melatonin timing

    Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 864–875

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind counterbalanced phase-response experiment · source_derived_draft · unverified_draft

    ### melatonin-phase-dead-zone The first half of habitual sleep corresponded to a region of minimal phase shifts in this protocol. Condition category: normal nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A sleep-promoting effect is not identical to resetting the clock. organism: 27 healthy young adults tissue_or_cell_type: Circadian melatonin timing experimental_model: Double-blind counterbalanced phase-response experiment limitations: Timing is relative to individual biological phase, not a universal clock hour. This experimental schedule is not a dosing instruction. exposure: 3 mg once daily for three days at different circadian times; dim-light onset measured evidence_span: {"source_cache": "artifacts/melatonin-research/18006583.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9eb1409f6e4c58eadfaf1554930378e03860dc9dc1201de6d104b6de784758ea", "start_char": 0, "end_char": 1518, "text_sha256": "9eb1409f6e4c58eadfaf1554930378e03860dc9dc1201de6d104b6de784758ea"} [melatonin-p18006583] A three pulse phase response curve to three milligrams of melatonin in humans. (2008). https://pubmed.ncbi.nlm.nih.gov/18006583/ DOI: 10.1113/jphysiol.2007.143180
    Complete structured claim and evidence

  3. The phase-delay response peaked about eleven hours after dim-light melatonin onset.

    Melatonin → Phase of the endogenous melatonin circadian rhythm source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/melatonin-research/18006583.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9eb1409f6e4c58eadfaf1554930378e03860dc9dc1201de6d104b6de784758ea", "start_char": 0, "end_char": 1518, "text_sha256": "9eb1409f6e4c58eadfaf1554930378e03860dc9dc1201de6d104b6de784758ea"}
    experimental_model
    Double-blind counterbalanced phase-response experiment
    exposure
    3 mg once daily for three days at different circadian times; dim-light onset measured
    limitations
    Timing is relative to individual biological phase, not a universal clock hour. This experimental schedule is not a dosing instruction.
    nutrient_topic
    Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
    organism
    27 healthy young adults
    plain_language
    A different timing can move the clock in the opposite direction.
    primary_references
    [melatonin-p18006583] A three pulse phase response curve to three milligrams of melatonin in humans. (2008). https://pubmed.ncbi.nlm.nih.gov/18006583/ DOI: 10.1113/jphysiol.2007.143180
    tissue_or_cell_type
    Circadian melatonin timing

    Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 851–862

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind counterbalanced phase-response experiment · source_derived_draft · unverified_draft

    ### melatonin-phase-delay The phase-delay response peaked about eleven hours after dim-light melatonin onset. Condition category: normal nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A different timing can move the clock in the opposite direction. organism: 27 healthy young adults tissue_or_cell_type: Circadian melatonin timing experimental_model: Double-blind counterbalanced phase-response experiment limitations: Timing is relative to individual biological phase, not a universal clock hour. This experimental schedule is not a dosing instruction. exposure: 3 mg once daily for three days at different circadian times; dim-light onset measured evidence_span: {"source_cache": "artifacts/melatonin-research/18006583.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9eb1409f6e4c58eadfaf1554930378e03860dc9dc1201de6d104b6de784758ea", "start_char": 0, "end_char": 1518, "text_sha256": "9eb1409f6e4c58eadfaf1554930378e03860dc9dc1201de6d104b6de784758ea"} [melatonin-p18006583] A three pulse phase response curve to three milligrams of melatonin in humans. (2008). https://pubmed.ncbi.nlm.nih.gov/18006583/ DOI: 10.1113/jphysiol.2007.143180
    Complete structured claim and evidence

  4. Caffeine three hours before habitual bedtime delayed the human melatonin rhythm by approximately 40 minutes.

    Caffeine → Phase of the endogenous melatonin circadian rhythm source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Double-blind within-subject circadian experiment lasting about 49 days.
    limitations
    A study-specific phase shift, not a fixed effect in every person; endogenous timing differs from clearance of a melatonin supplement.
    nutrient_topic
    Caffeine collection; salts, coffee, species and coexposure contexts retain their identities. · Caffeine
    plain_language
    Caffeine shifted internal timing as well as wakefulness.
    primary_references
    Effects of caffeine on the human circadian clock in vivo and in vitro. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26378246/ · DOI 10.1126/scitranslmed.aac5125

    Caffeine: receptors, metabolism, nutrient interactions, adaptation and discovery questions (2026-09-18) · lines 76–82

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Double-blind within-subject circadian experiment lasting about 49 days. · source_derived_draft · unverified_draft

    ## caf-clock-human Caffeine shifted internal timing as well as wakefulness. Caffeine three hours before habitual bedtime delayed the human melatonin rhythm by approximately 40 minutes. Model: Double-blind within-subject circadian experiment lasting about 49 days. Limitations: A study-specific phase shift, not a fixed effect in every person; endogenous timing differs from clearance of a melatonin supplement. Evidence access: Primary abstract Effects of caffeine on the human circadian clock in vivo and in vitro. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26378246/ · DOI 10.1126/scitranslmed.aac5125
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards