Component
Manganese(II) sulfate
Manganese(II) sulfate. Experimental scope belongs to each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Manganese sulfate treatment corrected the measured biochemical dysfunctions, including glycosylation, in the two SLC39A8-deficient patients.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- Human ZIP8 (SLC39A8) (affected_protein); Manganese (administered_element)
- evidence_span
- {"source_cache": "artifacts/manganese-clinical-sources/park2018.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "30cd68e96efec971f2e431d24f5b2a45c680ce0b5efe572e30d76aee758563f5", "start_char": 0, "end_char": 1522, "text_sha256": "30cd68e96efec971f2e431d24f5b2a45c680ce0b5efe572e30d76aee758563f5", "text_characters": 1522}
- experimental_model
- Manganese treatment report in two patients with SLC39A8 deficiency
- exposure
- 15 and 20 mg MnSO4/kg body weight/day as reported in the indexed abstract, with blood manganese, glycosylation and MRI monitoring.
- limitations
- Amounts describe manganese sulfate mass, not elemental manganese. Hydration state is not verified from this abstract, so no elemental conversion is made. Small uncontrolled rare-disease series; follow-up of previously described disease, not a general supplementation trial.
- nutrient_topic
- Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
- organism
- Homo sapiens
- plain_language
- Supplying manganese improved the measured biochemical abnormalities in these patients.
- primary_references
- [mn-clin-park2018] SLC39A8 deficiency: biochemical correction and major clinical improvement by manganese therapy. (2018). https://pubmed.ncbi.nlm.nih.gov/28749473/ DOI: 10.1038/gim.2017.106
- tissue_or_cell_type
- Biochemical and neurological outcomes
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 1188–1200
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Manganese treatment report in two patients with SLC39A8 deficiency · source_derived_draft · unverified_draft
### mn-clin-zip8-manganese-biochemical Manganese sulfate treatment corrected the measured biochemical dysfunctions, including glycosylation, in the two SLC39A8-deficient patients. Condition category: machinery_impairment nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Supplying manganese improved the measured biochemical abnormalities in these patients. organism: Homo sapiens tissue_or_cell_type: Biochemical and neurological outcomes experimental_model: Manganese treatment report in two patients with SLC39A8 deficiency limitations: Amounts describe manganese sulfate mass, not elemental manganese. Hydration state is not verified from this abstract, so no elemental conversion is made. Small uncontrolled rare-disease series; follow-up of previously described disease, not a general supplementation trial. exposure: 15 and 20 mg MnSO4/kg body weight/day as reported in the indexed abstract, with blood manganese, glycosylation and MRI monitoring. cross_nutrient: Human ZIP8 (SLC39A8) (affected_protein); Manganese (administered_element) evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/park2018.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "30cd68e96efec971f2e431d24f5b2a45c680ce0b5efe572e30d76aee758563f5", "start_char": 0, "end_char": 1522, "text_sha256": "30cd68e96efec971f2e431d24f5b2a45c680ce0b5efe572e30d76aee758563f5", "text_characters": 1522} [mn-clin-park2018] SLC39A8 deficiency: biochemical correction and major clinical improvement by manganese therapy. (2018). https://pubmed.ncbi.nlm.nih.gov/28749473/ DOI: 10.1038/gim.2017.106
Complete structured claim and evidenceMotor abilities, hearing and other neurological manifestations improved during monitored manganese treatment in the two-patient report.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- Human ZIP8 (SLC39A8) (affected_protein)
- evidence_span
- {"source_cache": "artifacts/manganese-clinical-sources/park2018.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "30cd68e96efec971f2e431d24f5b2a45c680ce0b5efe572e30d76aee758563f5", "start_char": 0, "end_char": 1522, "text_sha256": "30cd68e96efec971f2e431d24f5b2a45c680ce0b5efe572e30d76aee758563f5", "text_characters": 1522}
- experimental_model
- Manganese treatment report in two patients with SLC39A8 deficiency
- exposure
- 15 and 20 mg MnSO4/kg body weight/day as reported in the indexed abstract, with blood manganese, glycosylation and MRI monitoring.
- limitations
- Amounts describe manganese sulfate mass, not elemental manganese. Hydration state is not verified from this abstract, so no elemental conversion is made. Small uncontrolled rare-disease series; follow-up of previously described disease, not a general supplementation trial.
- nutrient_topic
- Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
- organism
- Homo sapiens
- plain_language
- Biochemical improvement was accompanied by clinical improvement.
- primary_references
- [mn-clin-park2018] SLC39A8 deficiency: biochemical correction and major clinical improvement by manganese therapy. (2018). https://pubmed.ncbi.nlm.nih.gov/28749473/ DOI: 10.1038/gim.2017.106
- tissue_or_cell_type
- Biochemical and neurological outcomes
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 1202–1214
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Manganese treatment report in two patients with SLC39A8 deficiency · source_derived_draft · unverified_draft
### mn-clin-zip8-manganese-clinical Motor abilities, hearing and other neurological manifestations improved during monitored manganese treatment in the two-patient report. Condition category: machinery_impairment nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Biochemical improvement was accompanied by clinical improvement. organism: Homo sapiens tissue_or_cell_type: Biochemical and neurological outcomes experimental_model: Manganese treatment report in two patients with SLC39A8 deficiency limitations: Amounts describe manganese sulfate mass, not elemental manganese. Hydration state is not verified from this abstract, so no elemental conversion is made. Small uncontrolled rare-disease series; follow-up of previously described disease, not a general supplementation trial. exposure: 15 and 20 mg MnSO4/kg body weight/day as reported in the indexed abstract, with blood manganese, glycosylation and MRI monitoring. cross_nutrient: Human ZIP8 (SLC39A8) (affected_protein) evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/park2018.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "30cd68e96efec971f2e431d24f5b2a45c680ce0b5efe572e30d76aee758563f5", "start_char": 0, "end_char": 1522, "text_sha256": "30cd68e96efec971f2e431d24f5b2a45c680ce0b5efe572e30d76aee758563f5", "text_characters": 1522} [mn-clin-park2018] SLC39A8 deficiency: biochemical correction and major clinical improvement by manganese therapy. (2018). https://pubmed.ncbi.nlm.nih.gov/28749473/ DOI: 10.1038/gim.2017.106
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.