Component
Experimental cathepsin B/D/L inhibitor combination
Combined inhibitors used on human thyroid lysosomal extracts, including pepstatin and diazomethylketone cysteine-proteinase inhibitors.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Combined inhibition of cathepsins B, D and L reduced long-incubation iodoamino-acid release from radioiodinated rabbit TG by 80–90%.
Experimental context and source evidence
- cross_nutrient
- false
- evidence_span
- {"source_cache": "artifacts/iodine-synthesis-sources/1903699.json", "json_field": "abstractText", "text_sha256": "2fecda8478b67ba815425948ac7198157a2d0e8fe18381b9bf3a9fd0e5190410", "text_characters": 2209, "note": "Exact publisher passage retained in the cited local source cache; locator and digest supplied here."}
- experimental_model
- In-vivo-radioiodinated rabbit TG incubated with human thyroid lysosomal extracts and protease inhibitors
- exposure
- Rabbit [125I]TG with human thyroid lysosomal extracts: 20–45 minutes for peptides; 8 and 24 hours for iodoamino-acid release. Combined protease inhibition.
- limitations
- Iodoamino-acid endpoint includes iodothyronines and iodotyrosines; do not assign the percentage specifically to T4.
- nutrient_topic
- Iodine research collection; topical membership is not evidence of a direct dietary effect. · Iodine
- organism
- Oryctolagus cuniculus substrate; Homo sapiens enzymes
- plain_language
- Blocking these proteases greatly reduced release of iodinated amino acids from TG.
- primary_references
- [iodine-syn-lysosome1991] Proteolytic processing of thyroglobulin by extracts of thyroid lysosomes. (1991). https://pubmed.ncbi.nlm.nih.gov/1903699/ DOI: 10.1210/endo-128-6-3073
- tissue_or_cell_type
- Human thyroid lysosomal extracts
Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17) · lines 674–686
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · In-vivo-radioiodinated rabbit TG incubated with human thyroid lysosomal extracts and protease inhibitors · source_derived_draft · unverified_draft
### iodine-syn-lysosomal-inhibition Combined inhibition of cathepsins B, D and L reduced long-incubation iodoamino-acid release from radioiodinated rabbit TG by 80–90%. Condition category: normal nutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Blocking these proteases greatly reduced release of iodinated amino acids from TG. organism: Oryctolagus cuniculus substrate; Homo sapiens enzymes tissue_or_cell_type: Human thyroid lysosomal extracts experimental_model: In-vivo-radioiodinated rabbit TG incubated with human thyroid lysosomal extracts and protease inhibitors limitations: Iodoamino-acid endpoint includes iodothyronines and iodotyrosines; do not assign the percentage specifically to T4. exposure: Rabbit [125I]TG with human thyroid lysosomal extracts: 20–45 minutes for peptides; 8 and 24 hours for iodoamino-acid release. Combined protease inhibition. cross_nutrient: false evidence_span: {"source_cache": "artifacts/iodine-synthesis-sources/1903699.json", "json_field": "abstractText", "text_sha256": "2fecda8478b67ba815425948ac7198157a2d0e8fe18381b9bf3a9fd0e5190410", "text_characters": 2209, "note": "Exact publisher passage retained in the cited local source cache; locator and digest supplied here."} [iodine-syn-lysosome1991] Proteolytic processing of thyroglobulin by extracts of thyroid lysosomes. (1991). https://pubmed.ncbi.nlm.nih.gov/1903699/ DOI: 10.1210/endo-128-6-3073
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.