Component
Acidity of the gastric lumen
Acidity of the gastric lumen. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Neither sodium salicylate nor acetylsalicylic acid given intravenously affected intramural pH or caused ulceration at luminal pH 7 or 3.5, but at luminal pH 1 both compounds caused ulceration and subtle changes in net ion fluxes without altering intramural pH, and since intravenous sodium salicylate and acetylsalicylic acid both cause ulceration but only acetylsalicylic acid alters prostaglandin synthesis, interference with prostaglandin metabolism does not appear to be a prerequisite for the occurrence of ulceration.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/aspirin-research/7064099.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b1e175ec209c9a177b7514b5931c3b02d3ca7c09a0d3629d55fcbd2b2f9088b4", "start_char": 0, "end_char": 1514, "text_sha256": "b1e175ec209c9a177b7514b5931c3b02d3ca7c09a0d3629d55fcbd2b2f9088b4"}
- experimental_model
- Measurement of intramural pH in the antral mucosa with ulceration scoring across luminal pH and routes of administration
- exposure
- Luminal and intravenous sodium salicylate and acetylsalicylic acid at luminal pH 7, 3.5 and 1
- limitations
- Separates the two compounds and the two routes against a controlled luminal acidity. The comparison of prostaglandin effects is stated rather than measured in this study.
- nutrient_topic
- Aspirin research collection; topical membership is not evidence of a direct clinical effect, and aspirin is recorded separately from salicylate, the metabolite it becomes. · Aspirin / acetylsalicylic acid
- organism
- Animal
- plain_language
- The metabolite, which does not touch prostaglandins, ulcerates the stomach just as the drug does, so prostaglandins are not the whole story.
- primary_references
- [asa-p7064099] Effects of sodium salicylate and acetylsalicylic acid on intramural pH and ulceration of rabbit antral mucosa. (1982). https://pubmed.ncbi.nlm.nih.gov/7064099/
- tissue_or_cell_type
- Gastric antral mucosa
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Measurement of intramural pH in the antral mucosa with ulceration scoring across luminal pH and routes of administration · source_derived_draft · unverified_draft
### asa-ulceration-without-prostaglandins Neither sodium salicylate nor acetylsalicylic acid given intravenously affected intramural pH or caused ulceration at luminal pH 7 or 3.5, but at luminal pH 1 both compounds caused ulceration and subtle changes in net ion fluxes without altering intramural pH, and since intravenous sodium salicylate and acetylsalicylic acid both cause ulceration but only acetylsalicylic acid alters prostaglandin synthesis, interference with prostaglandin metabolism does not appear to be a prerequisite for the occurrence of ulceration. Condition category: normal nutrient_topic: Aspirin research collection; topical membership is not evidence of a direct clinical effect, and aspirin is recorded separately from salicylate, the metabolite it becomes. plain_language: The metabolite, which does not touch prostaglandins, ulcerates the stomach just as the drug does, so prostaglandins are not the whole story. organism: Animal tissue_or_cell_type: Gastric antral mucosa experimental_model: Measurement of intramural pH in the antral mucosa with ulceration scoring across luminal pH and routes of administration limitations: Separates the two compounds and the two routes against a controlled luminal acidity. The comparison of prostaglandin effects is stated rather than measured in this study. exposure: Luminal and intravenous sodium salicylate and acetylsalicylic acid at luminal pH 7, 3.5 and 1 evidence_span: {"source_cache": "artifacts/aspirin-research/7064099.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b1e175ec209c9a177b7514b5931c3b02d3ca7c09a0d3629d55fcbd2b2f9088b4", "start_char": 0, "end_char": 1514, "text_sha256": "b1e175ec209c9a177b7514b5931c3b02d3ca7c09a0d3629d55fcbd2b2f9088b4"} [asa-p7064099] Effects of sodium salicylate and acetylsalicylic acid on intramural pH and ulceration of rabbit antral mucosa. (1982). https://pubmed.ncbi.nlm.nih.gov/7064099/
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.