{"id":"ed925394-344b-5014-9aa3-2b6a21c8c30d","stable_key":"f8641d02-8413-5bd8-92e9-62ad49286e81:asa-ulceration-without-prostaglandins","predicate":"causes","statement":"Neither sodium salicylate nor acetylsalicylic acid given intravenously affected intramural pH or caused ulceration at luminal pH 7 or 3.5, but at luminal pH 1 both compounds caused ulceration and subtle changes in net ion fluxes without altering intramural pH, and since intravenous sodium salicylate and acetylsalicylic acid both cause ulceration but only acetylsalicylic acid alters prostaglandin synthesis, interference with prostaglandin metabolism does not appear to be a prerequisite for the occurrence of ulceration.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"72b9bfd6-8b5b-5b32-923b-9744e2abefa1","mechanism_event_label":"The metabolite, which does not touch prostaglandins, ulcerates the stomach just as the drug does, so prostaglandins are not the whole story.","subject":{"id":"5739797a-3699-591b-95fd-f8b80e612713","slug":"salicylate","display_name":"Salicylate / salicylic acid","entity_type_key":"small_molecule"},"object":{"id":"bc682e5b-c41a-5ed3-9ed2-229ad36e43b6","slug":"gastric-ulceration","display_name":"Gastric antral mucosal ulceration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"72b9bfd6-8b5b-5b32-923b-9744e2abefa1","stable_key":"f8641d02-8413-5bd8-92e9-62ad49286e81:asa-ulceration-without-prostaglandins-event","event_type":"observed_intervention","label":"The metabolite, which does not touch prostaglandins, ulcerates the stomach just as the drug does, so prostaglandins are not the whole story.","description":"Neither sodium salicylate nor acetylsalicylic acid given intravenously affected intramural pH or caused ulceration at luminal pH 7 or 3.5, but at luminal pH 1 both compounds caused ulceration and subtle changes in net ion fluxes without altering intramural pH, and since intravenous sodium salicylate and acetylsalicylic acid both cause ulceration but only acetylsalicylic acid alters prostaglandin synthesis, interference with prostaglandin metabolism does not appear to be a prerequisite for the occurrence of ulceration.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8ac405bf-3ea0-539a-8e5e-abf503dc7081","slug":"aspirin","display_name":"Aspirin / acetylsalicylic acid","entity_type_key":"drug"},"role":"co_ulcerating_compound","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c8c56fc0-3a39-5dd6-a7e1-78546dafd97a","slug":"luminal-acidity","display_name":"Acidity of the gastric lumen","entity_type_key":"cellular_process"},"role":"required_condition","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6b07813a-a0a4-5844-99a3-90a4e4f58d4a","slug":"intramural-ph","display_name":"pH within the middle third of the antral mucosa","entity_type_key":"cellular_process"},"role":"measured_variable","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"5739797a-3699-591b-95fd-f8b80e612713","slug":"salicylate","display_name":"Salicylate / salicylic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"bc682e5b-c41a-5ed3-9ed2-229ad36e43b6","slug":"gastric-ulceration","display_name":"Gastric antral mucosal ulceration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/aspirin-research/7064099.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"b1e175ec209c9a177b7514b5931c3b02d3ca7c09a0d3629d55fcbd2b2f9088b4\", \"start_char\": 0, \"end_char\": 1514, \"text_sha256\": \"b1e175ec209c9a177b7514b5931c3b02d3ca7c09a0d3629d55fcbd2b2f9088b4\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Measurement of intramural pH in the antral mucosa with ulceration scoring across luminal pH and routes of administration","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Luminal and intravenous sodium salicylate and acetylsalicylic acid at luminal pH 7, 3.5 and 1","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Separates the two compounds and the two routes against a controlled luminal acidity. The comparison of prostaglandin effects is stated rather than measured in this study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Aspirin research collection; topical membership is not evidence of a direct clinical effect, and aspirin is recorded separately from salicylate, the metabolite it becomes.","comparator":null,"unit":null,"notes":"","entity":{"slug":"aspirin","display_name":"Aspirin / acetylsalicylic acid","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Animal","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The metabolite, which does not touch prostaglandins, ulcerates the stomach just as the drug does, so prostaglandins are not the whole story.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[asa-p7064099] Effects of sodium salicylate and acetylsalicylic acid on intramural pH and ulceration of rabbit antral mucosa. (1982). https://pubmed.ncbi.nlm.nih.gov/7064099/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Gastric antral mucosa","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"41c5ed26-95f7-5df5-9c0f-1653d5857772","evidence_kind":"source_excerpt","locator":"Lines 533-544","start_line":533,"end_line":544,"excerpt":"### asa-ulceration-without-prostaglandins\nNeither sodium salicylate nor acetylsalicylic acid given intravenously affected intramural pH or caused ulceration at luminal pH 7 or 3.5, but at luminal pH 1 both compounds caused ulceration and subtle changes in net ion fluxes without altering intramural pH, and since intravenous sodium salicylate and acetylsalicylic acid both cause ulceration but only acetylsalicylic acid alters prostaglandin synthesis, interference with prostaglandin metabolism does not appear to be a prerequisite for the occurrence of ulceration.\nCondition category: normal\nnutrient_topic: Aspirin research collection; topical membership is not evidence of a direct clinical effect, and aspirin is recorded separately from salicylate, the metabolite it becomes.\nplain_language: The metabolite, which does not touch prostaglandins, ulcerates the stomach just as the drug does, so prostaglandins are not the whole story.\norganism: Animal\ntissue_or_cell_type: Gastric antral mucosa\nexperimental_model: Measurement of intramural pH in the antral mucosa with ulceration scoring across luminal pH and routes of administration\nlimitations: Separates the two compounds and the two routes against a controlled luminal acidity. The comparison of prostaglandin effects is stated rather than measured in this study.\nexposure: Luminal and intravenous sodium salicylate and acetylsalicylic acid at luminal pH 7, 3.5 and 1\nevidence_span: {\"source_cache\": \"artifacts/aspirin-research/7064099.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"b1e175ec209c9a177b7514b5931c3b02d3ca7c09a0d3629d55fcbd2b2f9088b4\", \"start_char\": 0, \"end_char\": 1514, \"text_sha256\": \"b1e175ec209c9a177b7514b5931c3b02d3ca7c09a0d3629d55fcbd2b2f9088b4\"}\n[asa-p7064099] Effects of sodium salicylate and acetylsalicylic acid on intramural pH and ulceration of rabbit antral mucosa. (1982). https://pubmed.ncbi.nlm.nih.gov/7064099/","model_system":"Measurement of intramural pH in the antral mucosa with ulceration scoring across luminal pH and routes of administration","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [asa-p7064099] Effects of sodium salicylate and acetylsalicylic acid on intramural pH and ulceration of rabbit antral mucosa. (1982). https://pubmed.ncbi.nlm.nih.gov/7064099/","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"712cf519-cd27-5a8b-9e2f-961a98d7a27e","stable_key":"import-f8641d02-8413-5bd8-92e9-62ad49286e81","title":"Aspirin: the serine it acetylates, the enzyme that acetylation creates, the dose that separates platelet from vessel wall, and the metabolite that is a different drug (2026-09-22)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"93dd4343051c131e40d4fc3c95a978cd65478c13dcdb3f2d42507c49b09cb647","revision_id":"694e8ee7-49ca-5e6c-b58b-8ba8f82c2ad8","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}