Component
Human leukotriene C4 synthase / LTC4S
Human leukotriene C4 synthase / LTC4S. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Human LTC4S conjugates GSH with leukotriene A4 to make leukotriene C4.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/glutathione-research/20980252.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5eacc338c23e1f1be126ba80eebc8ac0ce7ea8735f22a5583dcebd7ef44eded4", "start_char": 0, "end_char": 1776, "text_sha256": "5eacc338c23e1f1be126ba80eebc8ac0ce7ea8735f22a5583dcebd7ef44eded4"}
- experimental_model
- LTC4S mutagenesis, spectroscopy and crystallography
- exposure
- Arg104 and Arg31 substitutions
- limitations
- GSH participates in inflammatory mediator synthesis; biochemical use does not imply that GSH supplements cause asthma.
- nutrient_topic
- Glutathione research collection; topical membership is not evidence of a direct dietary effect. · GSH
- organism
- Human
- plain_language
- Glutathione is also a building block for a signaling molecule.
- primary_references
- [glutathione-p20980252] Arginine 104 is a key catalytic residue in leukotriene C4 synthase. (2010). https://pubmed.ncbi.nlm.nih.gov/20980252/ DOI: 10.1074/jbc.m110.105940
- tissue_or_cell_type
- Purified membrane enzyme
Glutathione: metabolism, signaling and nutrient connections (2026-09-17) · lines 931–942
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · LTC4S mutagenesis, spectroscopy and crystallography · source_derived_draft · unverified_draft
### glutathione-ltc4s-product Human LTC4S conjugates GSH with leukotriene A4 to make leukotriene C4. Condition category: normal nutrient_topic: Glutathione research collection; topical membership is not evidence of a direct dietary effect. plain_language: Glutathione is also a building block for a signaling molecule. organism: Human tissue_or_cell_type: Purified membrane enzyme experimental_model: LTC4S mutagenesis, spectroscopy and crystallography limitations: GSH participates in inflammatory mediator synthesis; biochemical use does not imply that GSH supplements cause asthma. exposure: Arg104 and Arg31 substitutions evidence_span: {"source_cache": "artifacts/glutathione-research/20980252.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5eacc338c23e1f1be126ba80eebc8ac0ce7ea8735f22a5583dcebd7ef44eded4", "start_char": 0, "end_char": 1776, "text_sha256": "5eacc338c23e1f1be126ba80eebc8ac0ce7ea8735f22a5583dcebd7ef44eded4"} [glutathione-p20980252] Arginine 104 is a key catalytic residue in leukotriene C4 synthase. (2010). https://pubmed.ncbi.nlm.nih.gov/20980252/ DOI: 10.1074/jbc.m110.105940
Complete structured claim and evidence
What acts on it
Arg104 substitutions abolished 94.3–99.9% of LTC4S specific activity; selected variants lacked the GSH thiolate signal.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/glutathione-research/20980252.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5eacc338c23e1f1be126ba80eebc8ac0ce7ea8735f22a5583dcebd7ef44eded4", "start_char": 0, "end_char": 1776, "text_sha256": "5eacc338c23e1f1be126ba80eebc8ac0ce7ea8735f22a5583dcebd7ef44eded4"}
- experimental_model
- LTC4S mutagenesis, spectroscopy and crystallography
- exposure
- Arg104 and Arg31 substitutions
- limitations
- GSH participates in inflammatory mediator synthesis; biochemical use does not imply that GSH supplements cause asthma.
- nutrient_topic
- Glutathione research collection; topical membership is not evidence of a direct dietary effect. · GSH
- organism
- Human
- plain_language
- The enzyme activates the glutathione sulfur for conjugation.
- primary_references
- [glutathione-p20980252] Arginine 104 is a key catalytic residue in leukotriene C4 synthase. (2010). https://pubmed.ncbi.nlm.nih.gov/20980252/ DOI: 10.1074/jbc.m110.105940
- tissue_or_cell_type
- Purified membrane enzyme
Glutathione: metabolism, signaling and nutrient connections (2026-09-17) · lines 944–955
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · LTC4S mutagenesis, spectroscopy and crystallography · source_derived_draft · unverified_draft
### glutathione-ltc4s-r104 Arg104 substitutions abolished 94.3–99.9% of LTC4S specific activity; selected variants lacked the GSH thiolate signal. Condition category: normal nutrient_topic: Glutathione research collection; topical membership is not evidence of a direct dietary effect. plain_language: The enzyme activates the glutathione sulfur for conjugation. organism: Human tissue_or_cell_type: Purified membrane enzyme experimental_model: LTC4S mutagenesis, spectroscopy and crystallography limitations: GSH participates in inflammatory mediator synthesis; biochemical use does not imply that GSH supplements cause asthma. exposure: Arg104 and Arg31 substitutions evidence_span: {"source_cache": "artifacts/glutathione-research/20980252.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5eacc338c23e1f1be126ba80eebc8ac0ce7ea8735f22a5583dcebd7ef44eded4", "start_char": 0, "end_char": 1776, "text_sha256": "5eacc338c23e1f1be126ba80eebc8ac0ce7ea8735f22a5583dcebd7ef44eded4"} [glutathione-p20980252] Arginine 104 is a key catalytic residue in leukotriene C4 synthase. (2010). https://pubmed.ncbi.nlm.nih.gov/20980252/ DOI: 10.1074/jbc.m110.105940
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.