Component
LRRC8B/C/D/E partner subunits
LRRC8B/C/D/E partner subunits. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Deleting LRRC8A abolished VRAC currents; reconstitution required LRRC8A with another LRRC8 isoform.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/chloride-research/24790029.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9fc0ba50276b74ac5cd7aa29c4c8af4917132a43259b45363b5c16a19b775334", "start_char": 0, "end_char": 896, "text_sha256": "9fc0ba50276b74ac5cd7aa29c4c8af4917132a43259b45363b5c16a19b775334"}
- experimental_model
- Genome-wide screen, gene disruption and rescue
- exposure
- LRRC8 knockout and isoform coexpression
- limitations
- Channel composition and cellular volume response; no dietary intervention.
- nutrient_topic
- Chloride research collection; topical membership is not evidence of a direct dietary effect. · Chloride
- organism
- Human cell lines
- plain_language
- A swelling-responsive anion channel is a protein assembly, not one interchangeable subunit.
- primary_references
- [chloride-p24790029] Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC. (2014). https://pubmed.ncbi.nlm.nih.gov/24790029/ DOI: 10.1126/science.1252826
- tissue_or_cell_type
- Plasma membrane
Chloride: transport, acid-base balance, nutrient interactions and loss states (2026-09-17) · lines 471–482
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Genome-wide screen, gene disruption and rescue · source_derived_draft · unverified_draft
### chloride-lrrc8a-vrac Deleting LRRC8A abolished VRAC currents; reconstitution required LRRC8A with another LRRC8 isoform. Condition category: normal nutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect. plain_language: A swelling-responsive anion channel is a protein assembly, not one interchangeable subunit. organism: Human cell lines tissue_or_cell_type: Plasma membrane experimental_model: Genome-wide screen, gene disruption and rescue limitations: Channel composition and cellular volume response; no dietary intervention. exposure: LRRC8 knockout and isoform coexpression evidence_span: {"source_cache": "artifacts/chloride-research/24790029.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9fc0ba50276b74ac5cd7aa29c4c8af4917132a43259b45363b5c16a19b775334", "start_char": 0, "end_char": 896, "text_sha256": "9fc0ba50276b74ac5cd7aa29c4c8af4917132a43259b45363b5c16a19b775334"} [chloride-p24790029] Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC. (2014). https://pubmed.ncbi.nlm.nih.gov/24790029/ DOI: 10.1126/science.1252826
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.