Component
Low-molecular-weight cellular chromium fraction
Low-molecular-weight cellular chromium fraction. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Most Cr(III) formed in Cr(VI)-treated cells was associated with high-molecular-mass ligands; cell lysis redistributed chromium into a low-molecular-weight fraction spectroscopically similar to reported chromodulin.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/chromium-research/17263387.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "912905b2fefe0745017faae62124fe077d3944cde635ae1012ff76fc33094b35", "start_char": 0, "end_char": 1638, "text_sha256": "912905b2fefe0745017faae62124fe077d3944cde635ae1012ff76fc33094b35"}
- experimental_model
- X-ray absorption and EPR before and after cell fractionation
- exposure
- Cr(VI)-treated cells; comparisons with model Cr(III) complexes
- limitations
- The artifact evidence concerns chromium(VI)-exposed cells and the tested isolation procedures. It does not negate the activity measured when an isolated peptide preparation is added to an enzyme assay.
- nutrient_topic
- Chromium research collection; topical membership is not evidence of a direct dietary effect. · Chromium
- organism
- Human A549/HepG2, hamster V79 and mouse C2C12 cells
- plain_language
- Some apparent chromodulin-like material formed during sample preparation, raising doubts about its identity as a pre-existing cellular signal.
- primary_references
- [chromium-p17263387] X-ray absorption and EPR spectroscopic studies of the biotransformations of chromium(VI) in mammalian cells. Is chromodulin an artifact of isolation methods? (2007). https://pubmed.ncbi.nlm.nih.gov/17263387/ DOI: 10.1021/ja063792r
- tissue_or_cell_type
- Intact and lysed cell preparations
Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17) · lines 237–248
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · X-ray absorption and EPR before and after cell fractionation · source_derived_draft · unverified_draft
### chromium-chromodulin-isolation-artifact Most Cr(III) formed in Cr(VI)-treated cells was associated with high-molecular-mass ligands; cell lysis redistributed chromium into a low-molecular-weight fraction spectroscopically similar to reported chromodulin. Condition category: normal nutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Some apparent chromodulin-like material formed during sample preparation, raising doubts about its identity as a pre-existing cellular signal. organism: Human A549/HepG2, hamster V79 and mouse C2C12 cells tissue_or_cell_type: Intact and lysed cell preparations experimental_model: X-ray absorption and EPR before and after cell fractionation limitations: The artifact evidence concerns chromium(VI)-exposed cells and the tested isolation procedures. It does not negate the activity measured when an isolated peptide preparation is added to an enzyme assay. exposure: Cr(VI)-treated cells; comparisons with model Cr(III) complexes evidence_span: {"source_cache": "artifacts/chromium-research/17263387.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "912905b2fefe0745017faae62124fe077d3944cde635ae1012ff76fc33094b35", "start_char": 0, "end_char": 1638, "text_sha256": "912905b2fefe0745017faae62124fe077d3944cde635ae1012ff76fc33094b35"} [chromium-p17263387] X-ray absorption and EPR spectroscopic studies of the biotransformations of chromium(VI) in mammalian cells. Is chromodulin an artifact of isolation methods? (2007). https://pubmed.ncbi.nlm.nih.gov/17263387/ DOI: 10.1021/ja063792r
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.