Component
Hepatic retinol stores
Independent biological entity. Read linked claims for experimental scope and context.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
LPS lowered circulating retinol without a detected decrease in liver or kidney retinol in vitamin A-sufficient rats.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- experimental_model
- LPS versus saline with food withdrawal.
- limitations
- Acute rat model; not every inflammatory illness follows the same kinetics.
- nutrient_topic
- Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Rattus norvegicus
- plain_language
- A low blood value did not mean the measured tissue stores had been emptied.
- primary_references
- [va-rosales1996] Effects of acute inflammation on plasma retinol, retinol-binding protein, and its mRNA in the liver and kidneys of vitamin A-sufficient rats (1996). https://pubmed.ncbi.nlm.nih.gov/8725149/ DOI: 10.1016/s0022-2275(20)42007-3
- tissue_or_cell_type
- Plasma, liver and kidney
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 1674–1683
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · LPS versus saline with food withdrawal. · source_derived_draft · unverified_draft
### va-lps-lowers-retinol-with-stores LPS lowered circulating retinol without a detected decrease in liver or kidney retinol in vitamin A-sufficient rats. Condition category: biomarker_context nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: A low blood value did not mean the measured tissue stores had been emptied. organism: Rattus norvegicus tissue_or_cell_type: Plasma, liver and kidney experimental_model: LPS versus saline with food withdrawal. limitations: Acute rat model; not every inflammatory illness follows the same kinetics. [va-rosales1996] Effects of acute inflammation on plasma retinol, retinol-binding protein, and its mRNA in the liver and kidneys of vitamin A-sufficient rats (1996). https://pubmed.ncbi.nlm.nih.gov/8725149/ DOI: 10.1016/s0022-2275(20)42007-3
Complete structured claim and evidenceSerum-retinol and isotope-modelled liver-store classifications disagreed in Thai and Zambian children; inflammation adjustment reduced false positives in the latter.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- experimental_model
- 37 Thai and 128 Zambian children.
- limitations
- Isotope-derived liver reserves are model estimates; these data do not establish universal diagnostic performance.
- nutrient_topic
- Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Homo sapiens
- plain_language
- Neither a normal nor a low serum result fully described reserves in these cohorts.
- primary_references
- [va-suri2015] Serum retinol concentrations demonstrate high specificity after correcting for inflammation but questionable sensitivity compared with liver stores calculated from isotope dilution in determining vitamin A deficiency in Thai and Zambian children (2015). https://pubmed.ncbi.nlm.nih.gov/26447158/ DOI: 10.3945/ajcn.115.113050
- tissue_or_cell_type
- Serum and inferred liver stores
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 1696–1705
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 37 Thai and 128 Zambian children. · source_derived_draft · unverified_draft
### va-serum-versus-isotope-classification Serum-retinol and isotope-modelled liver-store classifications disagreed in Thai and Zambian children; inflammation adjustment reduced false positives in the latter. Condition category: biomarker_context nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: Neither a normal nor a low serum result fully described reserves in these cohorts. organism: Homo sapiens tissue_or_cell_type: Serum and inferred liver stores experimental_model: 37 Thai and 128 Zambian children. limitations: Isotope-derived liver reserves are model estimates; these data do not establish universal diagnostic performance. [va-suri2015] Serum retinol concentrations demonstrate high specificity after correcting for inflammation but questionable sensitivity compared with liver stores calculated from isotope dilution in determining vitamin A deficiency in Thai and Zambian children (2015). https://pubmed.ncbi.nlm.nih.gov/26447158/ DOI: 10.3945/ajcn.115.113050
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.