{"id":"4f5f123f-93ca-5e91-8405-7b826ab5ffa0","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-lps-lowers-retinol-with-stores","predicate":"inflammation_reduces","statement":"LPS lowered circulating retinol without a detected decrease in liver or kidney retinol in vitamin A-sufficient rats.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c49b4bfa-48bc-588a-9a13-146fcdd85d43","mechanism_event_label":"A low blood value did not mean the measured tissue stores had been emptied.","subject":{"id":"e96aad69-74fb-55c6-8378-7d5c281003eb","slug":"lipopolysaccharide","display_name":"Lipopolysaccharide","entity_type_key":"chemical_species"},"object":{"id":"3d7326b1-abb8-5957-bc1b-9c7c9c98063b","slug":"plasma-retinol-concentration","display_name":"Plasma retinol concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c49b4bfa-48bc-588a-9a13-146fcdd85d43","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-lps-lowers-retinol-with-stores-event","event_type":"observed_intervention","label":"A low blood value did not mean the measured tissue stores had been emptied.","description":"LPS lowered circulating retinol without a detected decrease in liver or kidney retinol in vitamin A-sufficient rats.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"148c57d8-c658-5769-89e8-1194cef2a782","slug":"retinol","display_name":"All-trans-retinol","entity_type_key":"small_molecule"},"role":"measured_retinoid","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9e80a3f1-1b89-5d4e-af1a-a4110a48e355","slug":"liver-retinol-stores","display_name":"Hepatic retinol stores","entity_type_key":"cellular_process"},"role":"preserved_measurement","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e96aad69-74fb-55c6-8378-7d5c281003eb","slug":"lipopolysaccharide","display_name":"Lipopolysaccharide","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"3d7326b1-abb8-5957-bc1b-9c7c9c98063b","slug":"plasma-retinol-concentration","display_name":"Plasma retinol concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; 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Study references: [va-rosales1996] Effects of acute inflammation on plasma retinol, retinol-binding protein, and its mRNA in the liver and kidneys of vitamin A-sufficient rats (1996). https://pubmed.ncbi.nlm.nih.gov/8725149/ DOI: 10.1016/s0022-2275(20)42007-3","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0c5474e2-be48-547b-b287-9c07a59c9ff1","stable_key":"import-dff9f743-3766-5f20-a71e-d6d2bd5bfb6f","title":"Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b217224b262abbd77d6a0c8c9beefff9c022fae4d31e2a5273915d769b9a6546","revision_id":"61008909-871f-575c-b5e2-21542689ea3c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}