Component

Left ventricular ejection fraction

Independent biological entity. Read linked claims for experimental scope and context.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Six months of thiamine did not improve LVEF, exercise capacity or quality of life in 69 ambulatory patients. Baseline-adjusted LVEF was higher with placebo (38%) than thiamine (35%), P=0.047.

    Thiamine (vitamin B1) → Left ventricular ejection fraction source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    Placebo-controlled multicenter trial.
    exposure
    200 mg oral thiamine mononitrate daily versus placebo for six months; trial exposure only.
    limitations
    Dose, duration, participants and crossover versus parallel design differ from the earlier pilot; not a test of untreated beriberi or proof of universal cardiac harm.
    nutrient_topic
    Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
    organism
    Homo sapiens
    plain_language
    The larger trial did not reproduce improved pumping; its adjusted LVEF comparison favored placebo.
    primary_references
    [b1-keith2019] Thiamin supplementation does not improve left ventricular ejection fraction in ambulatory heart failure patients: a randomized controlled trial (2019). https://pubmed.ncbi.nlm.nih.gov/31504093/ DOI: 10.1093/ajcn/nqz192
    tissue_or_cell_type
    Heart imaging and function

    Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1684–1694

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Placebo-controlled multicenter trial. · source_derived_draft · unverified_draft

    ### b1-hf-larger-lvef-null Six months of thiamine did not improve LVEF, exercise capacity or quality of life in 69 ambulatory patients. Baseline-adjusted LVEF was higher with placebo (38%) than thiamine (35%), P=0.047. Condition category: normal nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The larger trial did not reproduce improved pumping; its adjusted LVEF comparison favored placebo. organism: Homo sapiens tissue_or_cell_type: Heart imaging and function experimental_model: Placebo-controlled multicenter trial. limitations: Dose, duration, participants and crossover versus parallel design differ from the earlier pilot; not a test of untreated beriberi or proof of universal cardiac harm. exposure: 200 mg oral thiamine mononitrate daily versus placebo for six months; trial exposure only. [b1-keith2019] Thiamin supplementation does not improve left ventricular ejection fraction in ambulatory heart failure patients: a randomized controlled trial (2019). https://pubmed.ncbi.nlm.nih.gov/31504093/ DOI: 10.1093/ajcn/nqz192
    Complete structured claim and evidence

  2. The nine-patient crossover trial reported an absolute LVEF treatment effect of 3.9 percentage points after 28 days.

    Thiamine (vitamin B1) → Left ventricular ejection fraction source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    Nine diuretic-treated patients; randomized crossover.
    exposure
    300 mg/day thiamine versus placebo for 28 days, six-week washout then crossover; trial exposure only.
    limitations
    Small pilot with short periods; not proof that all heart failure is B1 deficiency.
    nutrient_topic
    Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
    organism
    Homo sapiens
    plain_language
    A very small heart-failure trial reported improved pumping fraction.
    primary_references
    [b1-schoenenberger2012] Thiamine supplementation in symptomatic chronic heart failure: a randomized, double-blind, placebo-controlled, cross-over pilot study (2012). https://pubmed.ncbi.nlm.nih.gov/22057652/ DOI: 10.1007/s00392-011-0376-2
    tissue_or_cell_type
    Heart imaging

    Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1672–1682

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Nine diuretic-treated patients; randomized crossover. · source_derived_draft · unverified_draft

    ### b1-hf-pilot-lvef-positive The nine-patient crossover trial reported an absolute LVEF treatment effect of 3.9 percentage points after 28 days. Condition category: normal nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: A very small heart-failure trial reported improved pumping fraction. organism: Homo sapiens tissue_or_cell_type: Heart imaging experimental_model: Nine diuretic-treated patients; randomized crossover. limitations: Small pilot with short periods; not proof that all heart failure is B1 deficiency. exposure: 300 mg/day thiamine versus placebo for 28 days, six-week washout then crossover; trial exposure only. [b1-schoenenberger2012] Thiamine supplementation in symptomatic chronic heart failure: a randomized, double-blind, placebo-controlled, cross-over pilot study (2012). https://pubmed.ncbi.nlm.nih.gov/22057652/ DOI: 10.1007/s00392-011-0376-2
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards