Component
Human low-density lipoprotein receptor / LDLR
Human low-density lipoprotein receptor / LDLR. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Berberine increased LDLR expression through an ERK-dependent, SREBP-independent post-transcriptional mechanism in human hepatoma cells.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/berberine-research/15531889.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ac2a9817f85e5c1f4f520590f1f2cb1ca820cce75b79120852f616f7ce5bea2f", "start_char": 0, "end_char": 1032, "text_sha256": "ac2a9817f85e5c1f4f520590f1f2cb1ca820cce75b79120852f616f7ce5bea2f"}
- experimental_model
- Human hepatoma mRNA stability/promoter experiments, animal and small clinical arms
- exposure
- Berberine exposure with ERK-dependence assays
- limitations
- Clinical lipid outcomes do not directly prove this molecular route caused the human effect. Cell response was reported independent of SREBP.
- nutrient_topic
- Berberine research collection; topical membership is not evidence of a direct dietary effect. · Berberine
- organism
- Human hepatoma cells for molecular claims
- plain_language
- More LDL receptor can help cells remove LDL from circulation; the mechanism was tested in cells.
- primary_references
- [berberine-p15531889] Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. (2004). https://pubmed.ncbi.nlm.nih.gov/15531889/ DOI: 10.1038/nm1135
- tissue_or_cell_type
- LDLR post-transcriptional regulation
Berberine: metabolism, nutrient connections and drug interactions (2026-09-17) · lines 454–465
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human hepatoma mRNA stability/promoter experiments, animal and small clinical arms · source_derived_draft · unverified_draft
### berberine-ldlr-protein Berberine increased LDLR expression through an ERK-dependent, SREBP-independent post-transcriptional mechanism in human hepatoma cells. Condition category: normal nutrient_topic: Berberine research collection; topical membership is not evidence of a direct dietary effect. plain_language: More LDL receptor can help cells remove LDL from circulation; the mechanism was tested in cells. organism: Human hepatoma cells for molecular claims tissue_or_cell_type: LDLR post-transcriptional regulation experimental_model: Human hepatoma mRNA stability/promoter experiments, animal and small clinical arms limitations: Clinical lipid outcomes do not directly prove this molecular route caused the human effect. Cell response was reported independent of SREBP. exposure: Berberine exposure with ERK-dependence assays evidence_span: {"source_cache": "artifacts/berberine-research/15531889.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ac2a9817f85e5c1f4f520590f1f2cb1ca820cce75b79120852f616f7ce5bea2f", "start_char": 0, "end_char": 1032, "text_sha256": "ac2a9817f85e5c1f4f520590f1f2cb1ca820cce75b79120852f616f7ce5bea2f"} [berberine-p15531889] Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. (2004). https://pubmed.ncbi.nlm.nih.gov/15531889/ DOI: 10.1038/nm1135
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.