Component
Incidence of lactic acidosis during oral antidiabetes-drug use
Incidence of lactic acidosis during oral antidiabetes-drug use. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The crude incidence of lactic acidosis was 3.3 cases per 100,000 person-years among metformin users and 4.8 among sulfonylurea users, and relevant comorbidities known as risk factors were identifiable in all six cases.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/metformin-research/18782901.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1fb3a7b0fff3f288a6d6f3da8e2fea2746e2869eee8e4171fbf6568e48124243", "start_char": 0, "end_char": 1676, "text_sha256": "1fb3a7b0fff3f288a6d6f3da8e2fea2746e2869eee8e4171fbf6568e48124243"}
- experimental_model
- Nested case-control analysis in 50,048 people with type 2 diabetes in the UK General Practice Research Database
- exposure
- Current use of oral antidiabetes drugs
- limitations
- A population incidence estimate. Six cases in total is a very small numerator, and comorbidity was present in all of them.
- nutrient_topic
- Metformin research collection; topical membership is not evidence of a direct clinical effect, and pharmacological exposure is not dietary intake. · Metformin
- organism
- Human
- plain_language
- The event is very rare, and it was no more common than with the comparison drug.
- primary_references
- [metformin-p18782901] Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis. (2008). https://pubmed.ncbi.nlm.nih.gov/18782901/ DOI: 10.2337/dc08-1171
- tissue_or_cell_type
- Whole body
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Metformin: transport, molecular targets, gut mechanisms and nutrient interactions (2026-09-19) · lines 1451–1462
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Nested case-control analysis in 50,048 people with type 2 diabetes in the UK General Practice Research Database · source_derived_draft · unverified_draft
### metformin-lactic-acidosis-incidence The crude incidence of lactic acidosis was 3.3 cases per 100,000 person-years among metformin users and 4.8 among sulfonylurea users, and relevant comorbidities known as risk factors were identifiable in all six cases. Condition category: biomarker_context nutrient_topic: Metformin research collection; topical membership is not evidence of a direct clinical effect, and pharmacological exposure is not dietary intake. plain_language: The event is very rare, and it was no more common than with the comparison drug. organism: Human tissue_or_cell_type: Whole body experimental_model: Nested case-control analysis in 50,048 people with type 2 diabetes in the UK General Practice Research Database limitations: A population incidence estimate. Six cases in total is a very small numerator, and comorbidity was present in all of them. exposure: Current use of oral antidiabetes drugs evidence_span: {"source_cache": "artifacts/metformin-research/18782901.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1fb3a7b0fff3f288a6d6f3da8e2fea2746e2869eee8e4171fbf6568e48124243", "start_char": 0, "end_char": 1676, "text_sha256": "1fb3a7b0fff3f288a6d6f3da8e2fea2746e2869eee8e4171fbf6568e48124243"} [metformin-p18782901] Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis. (2008). https://pubmed.ncbi.nlm.nih.gov/18782901/ DOI: 10.2337/dc08-1171
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.