Component
KDM1A
Independent protein record; interpretation is limited by each linked claim and its study context.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
KDM1A/LSD1 oxidatively removes a methyl group from H3K4me2 through a flavin-dependent reaction.
Experimental context and source evidence
- experimental_model
- Purified LSD1 enzyme / histone assays and cellular RNA interference.
- limitations
- Do not extend this specific activity to trimethyllysine or every histone site. This reaction modifies lysine already in a protein. It does not show that extra oral lysine increases the reaction or improves a clinical outcome.
- organism
- Human
- plain_language
- Some lysine methyl marks can be erased by a flavin enzyme.
- primary_references
- [lsd1-2004] Histone demethylation mediated by the nuclear amine oxidase homolog LSD1 (2004). https://pubmed.ncbi.nlm.nih.gov/15620353/ DOI: 10.1016/j.cell.2004.12.012
- tissue_or_cell_type
- Not specified as a whole tissue; see experimental model.
L-Lysine: mechanism-first literature curation (2026-09-17) · lines 557–565
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified LSD1 enzyme / histone assays and cellular RNA interference. · source_derived_draft · unverified_draft
### kdm1a-h3k4-demethylation KDM1A/LSD1 oxidatively removes a methyl group from H3K4me2 through a flavin-dependent reaction. Plain language: Some lysine methyl marks can be erased by a flavin enzyme. Condition category: normal organism: Human tissue_or_cell_type: Not specified as a whole tissue; see experimental model. experimental_model: Purified LSD1 enzyme / histone assays and cellular RNA interference. limitations: Do not extend this specific activity to trimethyllysine or every histone site. This reaction modifies lysine already in a protein. It does not show that extra oral lysine increases the reaction or improves a clinical outcome. [lsd1-2004] Histone demethylation mediated by the nuclear amine oxidase homolog LSD1 (2004). https://pubmed.ncbi.nlm.nih.gov/15620353/ DOI: 10.1016/j.cell.2004.12.012
Complete structured claim and evidence
What acts on it
One of the dihydrocapsaicin metabolites obtained from intestinal fungal biotransformation showed significant inhibitory effect on lysine-specific demethylase 1 with a half-maximal inhibitory concentration of 1.99 micromolar.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/dihydrocapsaicin-research/36578383.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a36fc63af6f17ba1a551c87f5c73e288e9f468affcd39bcba5baad1ee1acf338", "start_char": 0, "end_char": 1090, "text_sha256": "a36fc63af6f17ba1a551c87f5c73e288e9f468affcd39bcba5baad1ee1acf338"}
- experimental_model
- Biotransformation of dihydrocapsaicin by four cultivated human intestinal fungal strains with NMR and HRESIMS structure determination
- exposure
- Dihydrocapsaicin incubated with cultivated human intestinal fungal strains
- limitations
- An in vitro biotransformation study with cultivated strains, not a gut community. The enzyme-inhibition result is a property of an isolated metabolite, not a demonstrated effect in an animal.
- nutrient_topic
- Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin
- organism
- Human intestinal fungi
- plain_language
- One of those fungal products blocks an enzyme that edits chromatin, at a low concentration.
- primary_references
- [dhc-p36578383] Biotransformation of dihydrocapsaicin by human intestinal fungi and the inhibitory effects of metabolites against LSD1. (2022). https://pubmed.ncbi.nlm.nih.gov/36578383/ DOI: 10.1016/j.heliyon.2022.e12325
- tissue_or_cell_type
- In vitro culture
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Biotransformation of dihydrocapsaicin by four cultivated human intestinal fungal strains with NMR and HRESIMS structure determination · source_derived_draft · unverified_draft
### dhc-fungal-metabolite-inhibits-lsd1 One of the dihydrocapsaicin metabolites obtained from intestinal fungal biotransformation showed significant inhibitory effect on lysine-specific demethylase 1 with a half-maximal inhibitory concentration of 1.99 micromolar. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: One of those fungal products blocks an enzyme that edits chromatin, at a low concentration. organism: Human intestinal fungi tissue_or_cell_type: In vitro culture experimental_model: Biotransformation of dihydrocapsaicin by four cultivated human intestinal fungal strains with NMR and HRESIMS structure determination limitations: An in vitro biotransformation study with cultivated strains, not a gut community. The enzyme-inhibition result is a property of an isolated metabolite, not a demonstrated effect in an animal. exposure: Dihydrocapsaicin incubated with cultivated human intestinal fungal strains evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/36578383.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a36fc63af6f17ba1a551c87f5c73e288e9f468affcd39bcba5baad1ee1acf338", "start_char": 0, "end_char": 1090, "text_sha256": "a36fc63af6f17ba1a551c87f5c73e288e9f468affcd39bcba5baad1ee1acf338"} [dhc-p36578383] Biotransformation of dihydrocapsaicin by human intestinal fungi and the inhibitory effects of metabolites against LSD1. (2022). https://pubmed.ncbi.nlm.nih.gov/36578383/ DOI: 10.1016/j.heliyon.2022.e12325
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.