Component
JZL184, a monoacylglycerol lipase inhibitor
JZL184, a monoacylglycerol lipase inhibitor. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
After repeated administration the MAGL inhibitor JZL184 lost its analgesic activity and produced cross-tolerance to CB1 agonists in mice, effects phenocopied by genetic disruption of Mgll, and chronic blockade also caused physical dependence and impaired endocannabinoid-dependent synaptic plasticity.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/thc-research/20729846.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9c812c031525007d63883a15d43c6f342366dba7fa85ad0a9fef7152aa47ee7d", "start_char": 0, "end_char": 1167, "text_sha256": "9c812c031525007d63883a15d43c6f342366dba7fa85ad0a9fef7152aa47ee7d"}
- experimental_model
- Repeated MAGL inhibitor administration in mice with genetic confirmation
- exposure
- Repeated JZL184 administration, with Mgll genetic disruption as confirmation
- limitations
- A tolerance result produced by raising the natural ligand rather than by giving a drug. The genetic phenocopy is what rules out an off-target effect of the inhibitor.
- nutrient_topic
- THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
- organism
- Mouse
- plain_language
- Flooding the system with its own messenger produces the same tolerance and dependence as the drug does.
- primary_references
- [thc-p20729846] Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. (2010). https://pubmed.ncbi.nlm.nih.gov/20729846/ DOI: 10.1038/nn.2616
- tissue_or_cell_type
- Nervous system
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 400–411
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Repeated MAGL inhibitor administration in mice with genetic confirmation · source_derived_draft · unverified_draft
### thc-magl-blockade-antagonism After repeated administration the MAGL inhibitor JZL184 lost its analgesic activity and produced cross-tolerance to CB1 agonists in mice, effects phenocopied by genetic disruption of Mgll, and chronic blockade also caused physical dependence and impaired endocannabinoid-dependent synaptic plasticity. Condition category: machinery_impairment nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: Flooding the system with its own messenger produces the same tolerance and dependence as the drug does. organism: Mouse tissue_or_cell_type: Nervous system experimental_model: Repeated MAGL inhibitor administration in mice with genetic confirmation limitations: A tolerance result produced by raising the natural ligand rather than by giving a drug. The genetic phenocopy is what rules out an off-target effect of the inhibitor. exposure: Repeated JZL184 administration, with Mgll genetic disruption as confirmation evidence_span: {"source_cache": "artifacts/thc-research/20729846.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9c812c031525007d63883a15d43c6f342366dba7fa85ad0a9fef7152aa47ee7d", "start_char": 0, "end_char": 1167, "text_sha256": "9c812c031525007d63883a15d43c6f342366dba7fa85ad0a9fef7152aa47ee7d"} [thc-p20729846] Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. (2010). https://pubmed.ncbi.nlm.nih.gov/20729846/ DOI: 10.1038/nn.2616
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.