Component
Iyd catalytic efficiency
Iyd catalytic efficiency
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Replacing FMN with 2-prime-deoxyFMN in human IYD lowered iodotyrosine dehalogenation efficiency by more than fivefold while increasing turnover number by more than sixfold.
Experimental context and source evidence
- cross_nutrient
- true
- evidence_span
- {"source_cache": "artifacts/iodine-synthesis-sources/37654510.txt", "start_char": 9069, "end_char": 10489, "text_sha256": "5e0dc84da55832b58d1a1ad6c3a327551b878ef108389abf34b7eda4dcc8b7a1", "text_characters": 1420, "note": "Exact publisher passage retained in the cited local source cache; locator and digest supplied here."}
- experimental_model
- Purified soluble human IYD reconstituted with FMN or synthetic 2-prime-deoxyFMN
- exposure
- Human IYD reconstituted with FMN or synthetic 2-prime-deoxyFMN; Table 1 kcat/Km 5.0 versus 0.97 x 10^3 M^-1 s^-1; kcat 0.052 versus 0.32 s^-1.
- limitations
- Synthetic cofactor substitution is not riboflavin deficiency; kcat/Km and kcat are different measurements. Table 1 native-FMN kinetic comparator is cited from previous work; reconstituted FMN was used for binding comparisons.
- nutrient_topic
- Iodine research collection; topical membership is not evidence of a direct dietary effect. · Iodine
- organism
- Homo sapiens recombinant protein
- plain_language
- A small change to FMN weakened overall substrate processing even though the saturated enzyme turned over faster.
- primary_references
- [iodine-syn-iyd2023] The 2'-hydroxy group of flavin mononucleotide influences the catalytic function and promiscuity of the flavoprotein iodotyrosine dehalogenase. (2023). https://pubmed.ncbi.nlm.nih.gov/37654510/ DOI: 10.1039/d3cb00094j
- tissue_or_cell_type
- Purified enzyme
Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17) · lines 730–742
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified soluble human IYD reconstituted with FMN or synthetic 2-prime-deoxyFMN · source_derived_draft · unverified_draft
### iodine-syn-iyd-cofactor-substitution Replacing FMN with 2-prime-deoxyFMN in human IYD lowered iodotyrosine dehalogenation efficiency by more than fivefold while increasing turnover number by more than sixfold. Condition category: normal nutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect. plain_language: A small change to FMN weakened overall substrate processing even though the saturated enzyme turned over faster. organism: Homo sapiens recombinant protein tissue_or_cell_type: Purified enzyme experimental_model: Purified soluble human IYD reconstituted with FMN or synthetic 2-prime-deoxyFMN limitations: Synthetic cofactor substitution is not riboflavin deficiency; kcat/Km and kcat are different measurements. Table 1 native-FMN kinetic comparator is cited from previous work; reconstituted FMN was used for binding comparisons. exposure: Human IYD reconstituted with FMN or synthetic 2-prime-deoxyFMN; Table 1 kcat/Km 5.0 versus 0.97 x 10^3 M^-1 s^-1; kcat 0.052 versus 0.32 s^-1. cross_nutrient: true evidence_span: {"source_cache": "artifacts/iodine-synthesis-sources/37654510.txt", "start_char": 9069, "end_char": 10489, "text_sha256": "5e0dc84da55832b58d1a1ad6c3a327551b878ef108389abf34b7eda4dcc8b7a1", "text_characters": 1420, "note": "Exact publisher passage retained in the cited local source cache; locator and digest supplied here."} [iodine-syn-iyd2023] The 2'-hydroxy group of flavin mononucleotide influences the catalytic function and promiscuity of the flavoprotein iodotyrosine dehalogenase. (2023). https://pubmed.ncbi.nlm.nih.gov/37654510/ DOI: 10.1039/d3cb00094j
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.