Component
Itaconyl-CoA
Itaconyl-CoA
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Itaconyl-CoA inactivated purified human MMUT by forming a stable adduct with the B12-derived deoxyadenosyl moiety.
Experimental context and source evidence
- cross_nutrient
- false
- evidence_location
- Primary abstract; indexed Results and Figure 3E
- experimental_model
- Purified human MMUT; inhibitor-product spectroscopy and analysis
- exposure
- Itaconyl-CoA exposure in the purified-enzyme assay
- limitations
- Mechanism-based inhibitor is distinct from physiological methylmalonyl-CoA; no human dietary effect inferred.
- nutrient_topic
- Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B12 (cobalamins)
- organism
- Homo sapiens
- plain_language
- The itaconyl-CoA experiment trapped B12 radical chemistry and stopped the purified human enzyme.
- primary_references
- [ruetz-2019-itaconyl-radical] Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair. (2019). https://pubmed.ncbi.nlm.nih.gov/31672889/ DOI: 10.1126/science.aay0934
- tissue_or_cell_type
- Purified protein assay
Vitamin B12: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1384–1396
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified human MMUT; inhibitor-product spectroscopy and analysis · source_derived_draft · unverified_draft
### itaconyl-coa-inactivates-human-mmut Itaconyl-CoA inactivated purified human MMUT by forming a stable adduct with the B12-derived deoxyadenosyl moiety. Condition category: normal nutrient_topic: Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The itaconyl-CoA experiment trapped B12 radical chemistry and stopped the purified human enzyme. organism: Homo sapiens tissue_or_cell_type: Purified protein assay experimental_model: Purified human MMUT; inhibitor-product spectroscopy and analysis limitations: Mechanism-based inhibitor is distinct from physiological methylmalonyl-CoA; no human dietary effect inferred. exposure: Itaconyl-CoA exposure in the purified-enzyme assay cross_nutrient: false evidence_location: Primary abstract; indexed Results and Figure 3E [ruetz-2019-itaconyl-radical] Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair. (2019). https://pubmed.ncbi.nlm.nih.gov/31672889/ DOI: 10.1126/science.aay0934
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.