Component
Neovascularisation of irradiated distracted bone
Neovascularisation of irradiated distracted bone. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The angiogenic response was markedly increased by hyperbaric oxygen, with blood vessels more numerous in the central region than peripheral regions in irradiated animals given the treatment, a pattern absent in irradiated animals without it.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/hbot-research/15050074.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1fe4a8f81ae5308f452c7a4551e9de0f0426daf32cbcd153149ec6e6a7a61970", "start_char": 0, "end_char": 1615, "text_sha256": "1fe4a8f81ae5308f452c7a4551e9de0f0426daf32cbcd153149ec6e6a7a61970"}
- experimental_model
- Irradiated and non-irradiated rabbit mandibular distraction osteogenesis with fluoride autoradiography
- exposure
- 2.5 ATA for 90 minutes daily, 18 sessions preoperatively, after 22.4 Gy irradiation
- limitations
- A pre-treatment protocol in irradiated bone. Osteoblastic activity was measured by fluoride uptake, an activity surrogate.
- nutrient_topic
- Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Hyperbaric oxygen therapy
- organism
- Rabbit
- plain_language
- The new vessels came back in the pattern healthy bone shows.
- primary_references
- [hbot-p15050074] Osteoblastic activity and neoangiogenesis in distracted bone of irradiated rabbit mandible with or without hyperbaric oxygen treatment. (2004). https://pubmed.ncbi.nlm.nih.gov/15050074/ DOI: 10.1054/ijom.2003.0489
- tissue_or_cell_type
- Mandibular bone
Hyperbaric oxygen: the exposure, its reactive species, the signals they carry, and the nutrient-dependent enzymes that handle them (2026-09-19) · lines 1024–1035
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Irradiated and non-irradiated rabbit mandibular distraction osteogenesis with fluoride autoradiography · source_derived_draft · unverified_draft
### hbot-bone-neovascularisation The angiogenic response was markedly increased by hyperbaric oxygen, with blood vessels more numerous in the central region than peripheral regions in irradiated animals given the treatment, a pattern absent in irradiated animals without it. Condition category: normal nutrient_topic: Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: The new vessels came back in the pattern healthy bone shows. organism: Rabbit tissue_or_cell_type: Mandibular bone experimental_model: Irradiated and non-irradiated rabbit mandibular distraction osteogenesis with fluoride autoradiography limitations: A pre-treatment protocol in irradiated bone. Osteoblastic activity was measured by fluoride uptake, an activity surrogate. exposure: 2.5 ATA for 90 minutes daily, 18 sessions preoperatively, after 22.4 Gy irradiation evidence_span: {"source_cache": "artifacts/hbot-research/15050074.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1fe4a8f81ae5308f452c7a4551e9de0f0426daf32cbcd153149ec6e6a7a61970", "start_char": 0, "end_char": 1615, "text_sha256": "1fe4a8f81ae5308f452c7a4551e9de0f0426daf32cbcd153149ec6e6a7a61970"} [hbot-p15050074] Osteoblastic activity and neoangiogenesis in distracted bone of irradiated rabbit mandible with or without hyperbaric oxygen treatment. (2004). https://pubmed.ncbi.nlm.nih.gov/15050074/ DOI: 10.1054/ijom.2003.0489
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.