Component
Inulin
Inulin. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Inulin but not resistant starch significantly increased the short-chain fatty acid area under the curve from 4 to 6 hours, yet neither affected the GLP-1 or PYY area under the curve, while ghrelin at 6 hours after inulin was significantly lower than after glucose and the change in short-chain fatty acid area was negatively related to the change in ghrelin area; responses did not differ significantly between lean and overweight subjects.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/acetate-research/27966574.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7c0282e2d96baff8a6dde713af91c9df8641d7075c78cf1453ee7d74f6016cd3", "start_char": 0, "end_char": 1724, "text_sha256": "7c0282e2d96baff8a6dde713af91c9df8641d7075c78cf1453ee7d74f6016cd3"}
- experimental_model
- Randomised single-blind crossover in 13 overweight or obese and 12 lean humans
- exposure
- 75 g glucose alone, or with 24 g inulin or 28.2 g resistant starch, with blood sampled over 6 hours
- limitations
- The ligand did rise: inulin significantly increased the 4 to 6 hour short-chain fatty acid area under the curve. The authors note that a longer adaptation or a larger sample might give a different answer.
- nutrient_topic
- Acetic acid research collection; topical membership is not evidence of a direct clinical effect, and the ingested acid is recorded separately from the circulating acetate anion. · Acetic acid
- organism
- Human
- plain_language
- In people the fatty acids rose and the two appetite hormones did not move, though ghrelin fell.
- primary_references
- [acetate-p27966574] Acute increases in serum colonic short-chain fatty acids elicited by inulin do not increase GLP-1 or PYY responses but may reduce ghrelin in lean and overweight humans. (2017). https://pubmed.ncbi.nlm.nih.gov/27966574/ DOI: 10.1038/ejcn.2016.249
- tissue_or_cell_type
- Whole body
Acetic acid: the ingested acid, the receptors acetate binds, the acetyl-CoA it becomes, and the acetyl groups that reach histones (2026-09-21) · lines 368–379
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomised single-blind crossover in 13 overweight or obese and 12 lean humans · source_derived_draft · unverified_draft
### acetate-no-human-glp1 Inulin but not resistant starch significantly increased the short-chain fatty acid area under the curve from 4 to 6 hours, yet neither affected the GLP-1 or PYY area under the curve, while ghrelin at 6 hours after inulin was significantly lower than after glucose and the change in short-chain fatty acid area was negatively related to the change in ghrelin area; responses did not differ significantly between lean and overweight subjects. Condition category: normal nutrient_topic: Acetic acid research collection; topical membership is not evidence of a direct clinical effect, and the ingested acid is recorded separately from the circulating acetate anion. plain_language: In people the fatty acids rose and the two appetite hormones did not move, though ghrelin fell. organism: Human tissue_or_cell_type: Whole body experimental_model: Randomised single-blind crossover in 13 overweight or obese and 12 lean humans limitations: The ligand did rise: inulin significantly increased the 4 to 6 hour short-chain fatty acid area under the curve. The authors note that a longer adaptation or a larger sample might give a different answer. exposure: 75 g glucose alone, or with 24 g inulin or 28.2 g resistant starch, with blood sampled over 6 hours evidence_span: {"source_cache": "artifacts/acetate-research/27966574.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7c0282e2d96baff8a6dde713af91c9df8641d7075c78cf1453ee7d74f6016cd3", "start_char": 0, "end_char": 1724, "text_sha256": "7c0282e2d96baff8a6dde713af91c9df8641d7075c78cf1453ee7d74f6016cd3"} [acetate-p27966574] Acute increases in serum colonic short-chain fatty acids elicited by inulin do not increase GLP-1 or PYY responses but may reduce ghrelin in lean and overweight humans. (2017). https://pubmed.ncbi.nlm.nih.gov/27966574/ DOI: 10.1038/ejcn.2016.249
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.