Component

Intracavernosal pressure

Intracavernosal pressure. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. The effects of pelvic nerve stimulation on intracavernosal pressure and penile blood flow were blocked by N-omega-nitro-L-arginine in a dose-related manner confirming the role of nitric oxide, and intravenous sildenafil at 1 to 100 micrograms per kilogram had no direct effect on intracavernosal pressure but potentiated the increase induced by nerve stimulation at plasma concentrations consistent with its relaxation effect on isolated human cavernosal tissue and its inhibition of the enzyme in vitro, with no significant effect on blood pressure or heart rate.

    Sildenafil → Intracavernosal pressure source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/sildenafil-research/9628657.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "71870b989514f322eb55b17364921cc67de92b3deef59bdf75e2c35db6a97ff7", "start_char": 0, "end_char": 1781, "text_sha256": "71870b989514f322eb55b17364921cc67de92b3deef59bdf75e2c35db6a97ff7"}
    experimental_model
    Pentobarbital-anaesthetised dogs with pelvic nerve stimulation and nitric oxide synthase inhibition
    exposure
    Intravenous sildenafil 1 to 100 micrograms per kilogram, with N-omega-nitro-L-arginine
    limitations
    An in vivo test of the amplifier principle with the nitric oxide synthase inhibitor as the control. Anaesthetised animals.
    nutrient_topic
    Sildenafil research collection; topical membership is not evidence of a direct clinical effect, and the drug is recorded separately from its N-desmethyl metabolite and its target enzyme from the homologous retinal PDE6. · Sildenafil
    organism
    Dog
    plain_language
    In the living animal it raised nothing by itself and roughly doubled what the nerve was already doing.
    primary_references
    [sil-p9628657] Effect of the selective phosphodiesterase type 5 inhibitor sildenafil on erectile dysfunction in the anesthetized dog. (1998). https://pubmed.ncbi.nlm.nih.gov/9628657/ DOI: 10.1016/s0022-5347(01)63097-0
    tissue_or_cell_type
    Corpus cavernosum and systemic circulation
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Sildenafil: the enzyme it occupies instead of the substrate, why it cannot start a signal it can only preserve, the organic nitrate interaction that follows from that, the homologous retinal enzyme ten-fold away, and the pulmonary circulation where the same mechanism became a second indication (2026-09-22) · lines 301–312

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Pentobarbital-anaesthetised dogs with pelvic nerve stimulation and nitric oxide synthase inhibition · source_derived_draft · unverified_draft

    ### sil-potentiates-only-the-nerve-signal The effects of pelvic nerve stimulation on intracavernosal pressure and penile blood flow were blocked by N-omega-nitro-L-arginine in a dose-related manner confirming the role of nitric oxide, and intravenous sildenafil at 1 to 100 micrograms per kilogram had no direct effect on intracavernosal pressure but potentiated the increase induced by nerve stimulation at plasma concentrations consistent with its relaxation effect on isolated human cavernosal tissue and its inhibition of the enzyme in vitro, with no significant effect on blood pressure or heart rate. Condition category: biomarker_context nutrient_topic: Sildenafil research collection; topical membership is not evidence of a direct clinical effect, and the drug is recorded separately from its N-desmethyl metabolite and its target enzyme from the homologous retinal PDE6. plain_language: In the living animal it raised nothing by itself and roughly doubled what the nerve was already doing. organism: Dog tissue_or_cell_type: Corpus cavernosum and systemic circulation experimental_model: Pentobarbital-anaesthetised dogs with pelvic nerve stimulation and nitric oxide synthase inhibition limitations: An in vivo test of the amplifier principle with the nitric oxide synthase inhibitor as the control. Anaesthetised animals. exposure: Intravenous sildenafil 1 to 100 micrograms per kilogram, with N-omega-nitro-L-arginine evidence_span: {"source_cache": "artifacts/sildenafil-research/9628657.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "71870b989514f322eb55b17364921cc67de92b3deef59bdf75e2c35db6a97ff7", "start_char": 0, "end_char": 1781, "text_sha256": "71870b989514f322eb55b17364921cc67de92b3deef59bdf75e2c35db6a97ff7"} [sil-p9628657] Effect of the selective phosphodiesterase type 5 inhibitor sildenafil on erectile dysfunction in the anesthetized dog. (1998). https://pubmed.ncbi.nlm.nih.gov/9628657/ DOI: 10.1016/s0022-5347(01)63097-0
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. As a consequence of inhibition of PDE6 in the retina, sildenafil at 1 to 100 micromolar altered the kinetics of the light response of the isolated dog retina and in the anaesthetised dog modified the a-wave and b-wave of the electroretinogram induced by a flash of blue light, effects proportional to plasma concentrations, fully reversible, and occurring only following plasma concentrations approximately 30-fold higher than those active on intracavernosal pressure.

    Sildenafil → The electroretinogram a-wave and b-wave source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/sildenafil-research/10629850.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "af056c516b44e35eac7b0511ba3a8403ed84c347af6094ebc153f68c8ee7db92", "start_char": 0, "end_char": 2057, "text_sha256": "af056c516b44e35eac7b0511ba3a8403ed84c347af6094ebc153f68c8ee7db92"}
    experimental_model
    Enzyme selectivity panel with isolated tissue, anaesthetised dog haemodynamics and isolated retina
    exposure
    Sildenafil with and without nitric oxide drive, and against glyceryl trinitrate, sodium nitroprusside and milrinone
    limitations
    The single most complete pharmacological characterisation here, covering the target, the absence of effect without upstream drive, the nitrate potentiation, the absence of an inotropic effect, and the retinal effect in one series.
    nutrient_topic
    Sildenafil research collection; topical membership is not evidence of a direct clinical effect, and the drug is recorded separately from its N-desmethyl metabolite and its target enzyme from the homologous retinal PDE6. · Sildenafil
    organism
    Human, rabbit and dog
    plain_language
    The retinal enzyme is reached too, reversibly, but only at concentrations about thirty times the useful one.
    primary_references
    [sil-p10629850] The pharmacology of sildenafil, a novel and selective inhibitor of phosphodiesterase (PDE) type 5. (1999). https://pubmed.ncbi.nlm.nih.gov/10629850/ DOI: 10.1254/fpj.114.supplement_22
    tissue_or_cell_type
    Corpus cavernosum, aorta, cardiac trabeculae and retina

    Sildenafil: the enzyme it occupies instead of the substrate, why it cannot start a signal it can only preserve, the organic nitrate interaction that follows from that, the homologous retinal enzyme ten-fold away, and the pulmonary circulation where the same mechanism became a second indication (2026-09-22) · lines 288–299

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Enzyme selectivity panel with isolated tissue, anaesthetised dog haemodynamics and isolated retina · source_derived_draft · unverified_draft

    ### sil-retinal-effect-at-thirty-fold As a consequence of inhibition of PDE6 in the retina, sildenafil at 1 to 100 micromolar altered the kinetics of the light response of the isolated dog retina and in the anaesthetised dog modified the a-wave and b-wave of the electroretinogram induced by a flash of blue light, effects proportional to plasma concentrations, fully reversible, and occurring only following plasma concentrations approximately 30-fold higher than those active on intracavernosal pressure. Condition category: normal nutrient_topic: Sildenafil research collection; topical membership is not evidence of a direct clinical effect, and the drug is recorded separately from its N-desmethyl metabolite and its target enzyme from the homologous retinal PDE6. plain_language: The retinal enzyme is reached too, reversibly, but only at concentrations about thirty times the useful one. organism: Human, rabbit and dog tissue_or_cell_type: Corpus cavernosum, aorta, cardiac trabeculae and retina experimental_model: Enzyme selectivity panel with isolated tissue, anaesthetised dog haemodynamics and isolated retina limitations: The single most complete pharmacological characterisation here, covering the target, the absence of effect without upstream drive, the nitrate potentiation, the absence of an inotropic effect, and the retinal effect in one series. exposure: Sildenafil with and without nitric oxide drive, and against glyceryl trinitrate, sodium nitroprusside and milrinone evidence_span: {"source_cache": "artifacts/sildenafil-research/10629850.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "af056c516b44e35eac7b0511ba3a8403ed84c347af6094ebc153f68c8ee7db92", "start_char": 0, "end_char": 2057, "text_sha256": "af056c516b44e35eac7b0511ba3a8403ed84c347af6094ebc153f68c8ee7db92"} [sil-p10629850] The pharmacology of sildenafil, a novel and selective inhibitor of phosphodiesterase (PDE) type 5. (1999). https://pubmed.ncbi.nlm.nih.gov/10629850/ DOI: 10.1254/fpj.114.supplement_22
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards