Component
Intestinal luminal biotin availability
Intestinal luminal biotin availability. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Vancomycin-associated L. murinus expansion consumed residual gut biotin in the mouse experiments.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/biotin-research/28813664.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a672505b5121e4c99b21436c378624a7a8eca2576090dba1f59b4a989182e7a9", "start_char": 0, "end_char": 1065, "text_sha256": "a672505b5121e4c99b21436c378624a7a8eca2576090dba1f59b4a989182e7a9"}
- experimental_model
- SPF and gnotobiotic mouse experiments with diet, vancomycin and Lactobacillus murinus
- exposure
- Biotin-deprived diet plus microbiota manipulation
- limitations
- Mouse experimental ecology does not diagnose the cause of human alopecia or justify targeting a bacterial species in people.
- nutrient_topic
- Biotin research collection; topical membership is not evidence of a direct dietary effect. · Biotin
- organism
- Mus musculus
- plain_language
- A microbe can use the nutrient instead of supplying it.
- primary_references
- [b7-p28813664] Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice. (2017). https://pubmed.ncbi.nlm.nih.gov/28813664/ DOI: 10.1016/j.celrep.2017.07.057
- tissue_or_cell_type
- Gut microbiota and skin
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Biotin: carboxylases, recycling, deficiency and nutrient interactions (2026-09-17) · lines 1131–1142
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · SPF and gnotobiotic mouse experiments with diet, vancomycin and Lactobacillus murinus · source_derived_draft · unverified_draft
### b7-murinus-biotin Vancomycin-associated L. murinus expansion consumed residual gut biotin in the mouse experiments. Condition category: nutrient_deficiency nutrient_topic: Biotin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A microbe can use the nutrient instead of supplying it. organism: Mus musculus tissue_or_cell_type: Gut microbiota and skin experimental_model: SPF and gnotobiotic mouse experiments with diet, vancomycin and Lactobacillus murinus limitations: Mouse experimental ecology does not diagnose the cause of human alopecia or justify targeting a bacterial species in people. exposure: Biotin-deprived diet plus microbiota manipulation evidence_span: {"source_cache": "artifacts/biotin-research/28813664.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a672505b5121e4c99b21436c378624a7a8eca2576090dba1f59b4a989182e7a9", "start_char": 0, "end_char": 1065, "text_sha256": "a672505b5121e4c99b21436c378624a7a8eca2576090dba1f59b4a989182e7a9"} [b7-p28813664] Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice. (2017). https://pubmed.ncbi.nlm.nih.gov/28813664/ DOI: 10.1016/j.celrep.2017.07.057
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.