Component
Inducible prostaglandin E synthase
Inducible prostaglandin E synthase. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Acetaminophen inhibited lipopolysaccharide-induced whole blood prostaglandin E2 and thromboxane B2 production with half-maximal inhibitory concentrations of 44 and 94 micromolar, at therapeutic concentrations of 100 and 300 micromolar it reduced prostaglandin E2 more than thromboxane B2, but in isolated monocytes both were maximally reduced by only 60%, and at the same concentrations it caused a similar and incomplete inhibition of platelet prostaglandin E2 and thromboxane B2 during whole blood clotting, so that in the presence of plasma the drug almost completely suppressed inducible prostaglandin E2 biosynthesis through effects on both cyclooxygenase-2 and inducible prostaglandin E synthase.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/paracetamol-research/12598417.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e5796a25a03c77d12e8376a60aa094e481bd0c2ab58b29ddcb70027ab477b267", "start_char": 0, "end_char": 1894, "text_sha256": "e5796a25a03c77d12e8376a60aa094e481bd0c2ab58b29ddcb70027ab477b267"}
- experimental_model
- Human whole blood and isolated monocytes and platelets with parallel prostaglandin E2 and thromboxane B2 measurement
- exposure
- Acetaminophen at therapeutic plasma concentrations of 100 and 300 micromolar, in whole blood and in isolated cells
- limitations
- The whole blood against isolated cell comparison shows plasma components matter, and measuring two prostanoids in parallel separates the synthase from the downstream synthase. Ex vivo only.
- nutrient_topic
- Paracetamol research collection; topical membership is not evidence of a direct clinical effect, and the drug is recorded separately from the metabolites NAPQI and AM404. · Paracetamol
- organism
- Human
- plain_language
- In whole blood it nearly abolishes the inflammatory prostaglandin; in isolated cells it manages only sixty per cent.
- primary_references
- [apap-p12598417] Effects of acetaminophen on constitutive and inducible prostanoid biosynthesis in human blood cells. (2003). https://pubmed.ncbi.nlm.nih.gov/12598417/ DOI: 10.1038/sj.bjp.0705078
- tissue_or_cell_type
- Monocytes and platelets
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human whole blood and isolated monocytes and platelets with parallel prostaglandin E2 and thromboxane B2 measurement · source_derived_draft · unverified_draft
### apap-plasma-changes-the-answer Acetaminophen inhibited lipopolysaccharide-induced whole blood prostaglandin E2 and thromboxane B2 production with half-maximal inhibitory concentrations of 44 and 94 micromolar, at therapeutic concentrations of 100 and 300 micromolar it reduced prostaglandin E2 more than thromboxane B2, but in isolated monocytes both were maximally reduced by only 60%, and at the same concentrations it caused a similar and incomplete inhibition of platelet prostaglandin E2 and thromboxane B2 during whole blood clotting, so that in the presence of plasma the drug almost completely suppressed inducible prostaglandin E2 biosynthesis through effects on both cyclooxygenase-2 and inducible prostaglandin E synthase. Condition category: normal nutrient_topic: Paracetamol research collection; topical membership is not evidence of a direct clinical effect, and the drug is recorded separately from the metabolites NAPQI and AM404. plain_language: In whole blood it nearly abolishes the inflammatory prostaglandin; in isolated cells it manages only sixty per cent. organism: Human tissue_or_cell_type: Monocytes and platelets experimental_model: Human whole blood and isolated monocytes and platelets with parallel prostaglandin E2 and thromboxane B2 measurement limitations: The whole blood against isolated cell comparison shows plasma components matter, and measuring two prostanoids in parallel separates the synthase from the downstream synthase. Ex vivo only. exposure: Acetaminophen at therapeutic plasma concentrations of 100 and 300 micromolar, in whole blood and in isolated cells evidence_span: {"source_cache": "artifacts/paracetamol-research/12598417.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e5796a25a03c77d12e8376a60aa094e481bd0c2ab58b29ddcb70027ab477b267", "start_char": 0, "end_char": 1894, "text_sha256": "e5796a25a03c77d12e8376a60aa094e481bd0c2ab58b29ddcb70027ab477b267"} [apap-p12598417] Effects of acetaminophen on constitutive and inducible prostanoid biosynthesis in human blood cells. (2003). https://pubmed.ncbi.nlm.nih.gov/12598417/ DOI: 10.1038/sj.bjp.0705078
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.