Component
ICTUS global stroke recovery at 90 days
ICTUS global stroke recovery at 90 days. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Global recovery was similar with citicoline and placebo: odds ratio 1.03, 95% CI 0.86–1.25, p=0.364.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/choline-research/22691567.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d70010453da46567d129e81a98e9e077bc3c787880287428ddb76023202d5648", "start_char": 0, "end_char": 2066, "text_sha256": "d70010453da46567d129e81a98e9e077bc3c787880287428ddb76023202d5648"}
- experimental_model
- ICTUS randomized masked multicenter placebo-controlled trial
- exposure
- Citicoline 1000 mg every 12 hours, initially IV then oral for six weeks; 90-day recovery
- limitations
- Trial stopped for futility. Results apply to this clinical setting, not to nutritional essentiality or all choline forms.
- nutrient_topic
- Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
- organism
- Human
- plain_language
- The large stroke trial did not confirm a recovery benefit.
- primary_references
- [choline-p22691567] Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial). (2012). https://pubmed.ncbi.nlm.nih.gov/22691567/ DOI: 10.1016/s0140-6736(12)60813-7
- tissue_or_cell_type
- 2298 adults with moderate-to-severe acute ischemic stroke
Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 1335–1346
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · ICTUS randomized masked multicenter placebo-controlled trial · source_derived_draft · unverified_draft
### choline-citicoline-stroke-null Global recovery was similar with citicoline and placebo: odds ratio 1.03, 95% CI 0.86–1.25, p=0.364. Condition category: normal nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: The large stroke trial did not confirm a recovery benefit. organism: Human tissue_or_cell_type: 2298 adults with moderate-to-severe acute ischemic stroke experimental_model: ICTUS randomized masked multicenter placebo-controlled trial limitations: Trial stopped for futility. Results apply to this clinical setting, not to nutritional essentiality or all choline forms. exposure: Citicoline 1000 mg every 12 hours, initially IV then oral for six weeks; 90-day recovery evidence_span: {"source_cache": "artifacts/choline-research/22691567.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d70010453da46567d129e81a98e9e077bc3c787880287428ddb76023202d5648", "start_char": 0, "end_char": 2066, "text_sha256": "d70010453da46567d129e81a98e9e077bc3c787880287428ddb76023202d5648"} [choline-p22691567] Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial). (2012). https://pubmed.ncbi.nlm.nih.gov/22691567/ DOI: 10.1016/s0140-6736(12)60813-7
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.