Component
Human ZDHHC7 knockout in HEK293T
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
ZDHHC7 knockout decreased endogenous MAVS S-acylation in HEK293T.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- experimental_model
- Human HEK293T; endogenous proteins; acyl-biotin exchange
- exposure
- Genetic ZDHHC7 knockout.
- limitations
- Endogenous knockout is distinct from murine ZDHHC plasmid overexpression elsewhere in this paper. ABE measures S-acylation, not the abundance of a specified acyl chain.
- organism
- Human
- primary_locator
- Figure 1C; SI Figure S1E, n=5.
- primary_references
- https://doi.org/10.1073/pnas.2403392121
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
MAVS inhibitor nulls and APT2-TBK1 immune feedback · lines 33–39
Selected primary observations: 10.1073/pnas.2403392121; 10.1038/s41467-025-65081-8. · supports · Human HEK293T; endogenous proteins; acyl-biotin exchange · source_derived_draft · unverified_draft
ZDHHC7 knockout decreased endogenous MAVS S-acylation in HEK293T. primary_references: https://doi.org/10.1073/pnas.2403392121 primary_locator: Figure 1C; SI Figure S1E, n=5. organism: Human experimental_model: Human HEK293T; endogenous proteins; acyl-biotin exchange exposure: Genetic ZDHHC7 knockout. limitations: Endogenous knockout is distinct from murine ZDHHC plasmid overexpression elsewhere in this paper. ABE measures S-acylation, not the abundance of a specified acyl chain.
Complete structured claim and evidenceZDHHC7 knockout reduced MAVS aggregation after poly(I:C) stimulation in HEK293T.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- experimental_model
- Human HEK293T; wild-type versus ZDHHC7 knockout
- exposure
- Poly(I:C) transfection, 2 micrograms/mL for 8 hours.
- limitations
- Activation-dependent result. Crude P5 includes other organelles; this observation alone does not quantify purified mitochondrial localization.
- organism
- Human
- primary_locator
- Figure 1K; SDD-AGE of crude mitochondrial P5.
- primary_references
- https://doi.org/10.1073/pnas.2403392121
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
MAVS inhibitor nulls and APT2-TBK1 immune feedback · lines 42–48
Selected primary observations: 10.1073/pnas.2403392121; 10.1038/s41467-025-65081-8. · supports · Human HEK293T; wild-type versus ZDHHC7 knockout · source_derived_draft · unverified_draft
ZDHHC7 knockout reduced MAVS aggregation after poly(I:C) stimulation in HEK293T. primary_references: https://doi.org/10.1073/pnas.2403392121 primary_locator: Figure 1K; SDD-AGE of crude mitochondrial P5. organism: Human experimental_model: Human HEK293T; wild-type versus ZDHHC7 knockout exposure: Poly(I:C) transfection, 2 micrograms/mL for 8 hours. limitations: Activation-dependent result. Crude P5 includes other organelles; this observation alone does not quantify purified mitochondrial localization.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.