Component
Human plasma tryptophan during acute depletion
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
A tryptophan-free amino-acid drink lowered total and free plasma tryptophan by 70–80% after five hours in antidepressant responders.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_access
- Primary abstract
- experimental_model
- Thirty human antidepressant responders in depletion and control sessions.
- limitations
- An experimentally unbalanced drink differs from ordinary meals; plasma values are not direct brain serotonin assays.
- nutrient_topic
- Tryptophan collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Tryptophan
- plain_language
- A research depletion drink rapidly lowered circulating supply.
- primary_references
- Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: implications for the role of serotonin in the mechanism of antidepressant action. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10418696/ · DOI 10.1016/s0006-3223(99)00014-1
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Tryptophan: transport, protein synthesis, neuroactive metabolites, NAD and microbial pathways (2026-09-19) · lines 146–152
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Thirty human antidepressant responders in depletion and control sessions. · source_derived_draft · unverified_draft
## tryptophan-clinical-depletion A research depletion drink rapidly lowered circulating supply. A tryptophan-free amino-acid drink lowered total and free plasma tryptophan by 70–80% after five hours in antidepressant responders. Model: Thirty human antidepressant responders in depletion and control sessions. Limitations: An experimentally unbalanced drink differs from ordinary meals; plasma values are not direct brain serotonin assays. Evidence access: Primary abstract Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: implications for the role of serotonin in the mechanism of antidepressant action. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10418696/ · DOI 10.1016/s0006-3223(99)00014-1
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.