Component
DNA hypermethylation in TET2 germline mutation carriers
The proportion of hypermethylated loci in carriers relative to non-carrier family members.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
One year of oral vitamin C at 1 g/day in members of a family carrying a heterozygous truncating germline TET2 mutation reduced the proportion of hypermethylated loci and diminished gene-expression differences between carriers and non-carrier relatives.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- duration
- One year
- experimental_model
- Clinical trial of one year in a single lymphoma-predisposition family; genome-wide methylation and expression
- exposure
- Oral vitamin C 1 g/day
- limitations
- One family, no disease endpoint measured. A methylation change is a biomarker, not a demonstration that lymphoma risk fell. Registered as EudraCT 2018-000155-41.
- organism
- Homo sapiens
- plain_language
- A year of vitamin C shifted the DNA marks in people born with a damaged TET2, but no cancer outcome was measured.
- primary_references
- [pitkanen-2023] Vitamin C boosts DNA demethylation in TET2 germline mutation carriers (2023). https://pubmed.ncbi.nlm.nih.gov/36639817/ DOI: 10.1186/s13148-022-01404-6
- tissue
- Blood cells
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
TET2 loss and malignancy: the step between a nutrient-responsive enzyme and the disease (2026-09-23) · lines 193–201
Original AI-assisted curation of twelve primary studies located by Europe PMC title search, with every statement drafted from the retrieved abstract. Two pairs share a laboratory and are recorded as one line of evidence each. Genetic loss of function, pharmacological exposure and dietary depletion are kept as separate record types. Not publisher full text. · supports · Clinical trial of one year in a single lymphoma-predisposition family; genome-wide methylation and expression · source_derived_draft · unverified_draft
## vitamin-c-reduces-hypermethylation-in-tet2-carriers One year of oral vitamin C at 1 g/day in members of a family carrying a heterozygous truncating germline TET2 mutation reduced the proportion of hypermethylated loci and diminished gene-expression differences between carriers and non-carrier relatives. Model/species: Clinical trial of one year in a single lymphoma-predisposition family; genome-wide methylation and expression Organism: Homo sapiens Tissue/system: Blood cells Exposure: Oral vitamin C 1 g/day Duration: One year Limits: One family, no disease endpoint measured. A methylation change is a biomarker, not a demonstration that lymphoma risk fell. Registered as EudraCT 2018-000155-41. Primary reference: [pitkanen-2023] Vitamin C boosts DNA demethylation in TET2 germline mutation carriers (2023). https://pubmed.ncbi.nlm.nih.gov/36639817/ DOI: 10.1186/s13148-022-01404-6
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.