Component
Patient-derived human AML cell growth in taurine experiments
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
TAUT inhibition combined with venetoclax synergistically reduced growth of primary human AML cells in the reported experiments.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Ex-vivo human AML; venetoclax-resistance expression analyses.
- limitations
- Measured experimental combination effect, not a proven clinical interaction between taurine supplements and venetoclax.
- nutrient_topic
- Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Taurine
- plain_language
- Blocking nutrient uptake affected response to an anticancer drug in patient-derived cells.
- primary_references
- Taurine from tumour niche drives glycolysis to promote leukaemogenesis. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40369079/ · DOI 10.1038/s41586-025-09018-7
Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19) · lines 561–567
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Ex-vivo human AML; venetoclax-resistance expression analyses. · source_derived_draft · unverified_draft
## taurine-leukemia-venetoclax Blocking nutrient uptake affected response to an anticancer drug in patient-derived cells. TAUT inhibition combined with venetoclax synergistically reduced growth of primary human AML cells in the reported experiments. Model: Ex-vivo human AML; venetoclax-resistance expression analyses. Limitations: Measured experimental combination effect, not a proven clinical interaction between taurine supplements and venetoclax. Evidence access: Primary abstract Taurine from tumour niche drives glycolysis to promote leukaemogenesis. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40369079/ · DOI 10.1038/s41586-025-09018-7
Complete structured claim and evidenceInhibiting CDO1 in osteolineage cultures derived from AML patients reduced survival and colony formation of AML cells from the same patients.
Experimental context and source evidence
- evidence_access
- Primary full text, Figure 2h–i
- experimental_model
- Matched human stromal/AML cocultures.
- limitations
- Ex-vivo dependency does not establish an effective or safe clinical inhibitor.
- nutrient_topic
- Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Taurine
- plain_language
- Patient-derived support cells also provided a growth-supporting pathway.
- primary_references
- Taurine from tumour niche drives glycolysis to promote leukaemogenesis. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40369079/ · DOI 10.1038/s41586-025-09018-7
Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19) · lines 521–527
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Matched human stromal/AML cocultures. · source_derived_draft · unverified_draft
## taurine-niche-human-cdo1 Patient-derived support cells also provided a growth-supporting pathway. Inhibiting CDO1 in osteolineage cultures derived from AML patients reduced survival and colony formation of AML cells from the same patients. Model: Matched human stromal/AML cocultures. Limitations: Ex-vivo dependency does not establish an effective or safe clinical inhibitor. Evidence access: Primary full text, Figure 2h–i Taurine from tumour niche drives glycolysis to promote leukaemogenesis. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40369079/ · DOI 10.1038/s41586-025-09018-7
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.