Component
Self-reported stress, cognition and HPA response in healthy volunteers
Self-reported stress, cognition and HPA response in healthy volunteers. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
In an 8-week randomized placebo-controlled cross-over design with 29 healthy male volunteers there was no overall effect of probiotic treatment on measures of mood, anxiety, stress or sleep quality and no significant effect over placebo on subjective stress measures or the hypothalamic-pituitary-adrenal response to a socially evaluated cold pressor test, visuospatial memory performance, attention switching, rapid visual information processing, emotion recognition and associated electroencephalographic measures did not show improvement over placebo, and no significant anti-inflammatory effects were seen as assessed by basal and stimulated cytokine levels.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/gaba-research/27865949.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e575c804cff60d6e87ab46520788fa3619705071562c2c39ff2b6ea57d5552b2", "start_char": 0, "end_char": 2278, "text_sha256": "e575c804cff60d6e87ab46520788fa3619705071562c2c39ff2b6ea57d5552b2"}
- experimental_model
- Randomised placebo-controlled cross-over trial over eight weeks in healthy male volunteers
- exposure
- The same Lactobacillus rhamnosus JB-1 strain against placebo, with a socially evaluated cold pressor test
- limitations
- Twenty-nine healthy men, which is the population most likely to show nothing. The authors state the limitation and call for study in people with stress-related disorders.
- nutrient_topic
- GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in. · Gamma-aminobutyric acid
- organism
- Human
- plain_language
- The same bacterium given to healthy men changed nothing that was measured.
- primary_references
- [gb-p27865949] Lost in translation? The potential psychobiotic Lactobacillus rhamnosus (JB-1) fails to modulate stress or cognitive performance in healthy male subjects. (2017). https://pubmed.ncbi.nlm.nih.gov/27865949/ DOI: 10.1016/j.bbi.2016.11.018
- tissue_or_cell_type
- Behaviour, cortisol, cytokines and electroencephalography
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomised placebo-controlled cross-over trial over eight weeks in healthy male volunteers · source_derived_draft · unverified_draft
### gb-it-did-not-translate In an 8-week randomized placebo-controlled cross-over design with 29 healthy male volunteers there was no overall effect of probiotic treatment on measures of mood, anxiety, stress or sleep quality and no significant effect over placebo on subjective stress measures or the hypothalamic-pituitary-adrenal response to a socially evaluated cold pressor test, visuospatial memory performance, attention switching, rapid visual information processing, emotion recognition and associated electroencephalographic measures did not show improvement over placebo, and no significant anti-inflammatory effects were seen as assessed by basal and stimulated cytokine levels. Condition category: normal nutrient_topic: GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in. plain_language: The same bacterium given to healthy men changed nothing that was measured. organism: Human tissue_or_cell_type: Behaviour, cortisol, cytokines and electroencephalography experimental_model: Randomised placebo-controlled cross-over trial over eight weeks in healthy male volunteers limitations: Twenty-nine healthy men, which is the population most likely to show nothing. The authors state the limitation and call for study in people with stress-related disorders. exposure: The same Lactobacillus rhamnosus JB-1 strain against placebo, with a socially evaluated cold pressor test evidence_span: {"source_cache": "artifacts/gaba-research/27865949.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e575c804cff60d6e87ab46520788fa3619705071562c2c39ff2b6ea57d5552b2", "start_char": 0, "end_char": 2278, "text_sha256": "e575c804cff60d6e87ab46520788fa3619705071562c2c39ff2b6ea57d5552b2"} [gb-p27865949] Lost in translation? The potential psychobiotic Lactobacillus rhamnosus (JB-1) fails to modulate stress or cognitive performance in healthy male subjects. (2017). https://pubmed.ncbi.nlm.nih.gov/27865949/ DOI: 10.1016/j.bbi.2016.11.018
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.