Component
IFN-gamma circadian response in stimulated human whole blood
Species, preparation, dose and limitations are retained on linked claims.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
A single-dose placebo-controlled crossover trial found a significant shift in the IFN-gamma circadian profile after 3000 FIP units of oral bromelain.
Experimental context and source evidence
- dose
- Single oral dose; high dose 3000 FIP units
- duration
- Circadian sampling after one dose
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- Healthy human volunteers in a three-way crossover trial
- limitations
- The clinical relevance and effect in a diseased immune system were not established; IL-5 and IL-10 findings were trends.
- nutrient_topic
- Bromelain chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Bromelain
- organism
- Healthy human volunteers in a three-way crossover trial
- plain_language
- A single-dose placebo-controlled crossover trial found a significant shift in the IFN-gamma circadian profile after 3000 FIP units of oral bromelain.
- primary_references
- Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration - new evidence on the antiinflammatory mode of action of bromelain. (2013). https://pubmed.ncbi.nlm.nih.gov/22517542/ DOI: 10.1002/ptr.4678
- route
- Oral
- tissue
- Ex-vivo stimulated whole-blood cytokine profiles
Bromelain: mechanism of action and interactions (2026-09-20) · lines 99–108
Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Healthy human volunteers in a three-way crossover trial · source_derived_draft · unverified_draft
## bromelain-human-cytokine-shift A single-dose placebo-controlled crossover trial found a significant shift in the IFN-gamma circadian profile after 3000 FIP units of oral bromelain. Model/species: Healthy human volunteers in a three-way crossover trial Tissue/system: Ex-vivo stimulated whole-blood cytokine profiles Exposure: Single oral dose; high dose 3000 FIP units Route: Oral Duration: Circadian sampling after one dose Limits: The clinical relevance and effect in a diseased immune system were not established; IL-5 and IL-10 findings were trends. Primary reference: Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration - new evidence on the antiinflammatory mode of action of bromelain. (2013). https://pubmed.ncbi.nlm.nih.gov/22517542/ DOI: 10.1002/ptr.4678 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.