Component
Human SIT1 T199M proline transport capacity
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
SIT1 T199M reduced maximal proline-induced transport current about threefold, supporting a defect in gate dynamics implicated in iminoglycinuria.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Primary full text
- experimental_model
- Human SIT1 variant expressed in Xenopus oocytes with structural interpretation.
- limitations
- The proposed packing mechanism is an interpretation informed by structure, while reduced current was measured.
- nutrient_topic
- L-Proline collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Proline
- plain_language
- A transporter can reach the assay system yet move substrate less efficiently.
- primary_references
- Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38951531/ · DOI 10.1038/s41467-024-48921-x
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
L-Proline: synthesis, collagen processing, redox metabolism and cross-nutrient mechanisms (2026-09-19) · lines 198–204
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human SIT1 variant expressed in Xenopus oocytes with structural interpretation. · source_derived_draft · unverified_draft
## l-proline-sit1-variant A transporter can reach the assay system yet move substrate less efficiently. SIT1 T199M reduced maximal proline-induced transport current about threefold, supporting a defect in gate dynamics implicated in iminoglycinuria. Model: Human SIT1 variant expressed in Xenopus oocytes with structural interpretation. Limitations: The proposed packing mechanism is an interpretation informed by structure, while reduced current was measured. Evidence access: Primary full text Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38951531/ · DOI 10.1038/s41467-024-48921-x
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.