Component
Human renal SLC5A6 promoter activity
Human renal SLC5A6 promoter activity. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Ethanol-exposed HK-2 cells showed reduced activity of the human SLC5A6 regulatory region.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/biotin-research/21209005.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b42defcb27acffce0c264240e14b0535770f94627ee5a4836b284e4e0971b5a0", "start_char": 0, "end_char": 1797, "text_sha256": "b42defcb27acffce0c264240e14b0535770f94627ee5a4836b284e4e0971b5a0"}
- experimental_model
- Chronic ethanol exposure in renal HK-2 cells and separate rodents
- exposure
- Chronic ethanol exposure
- limitations
- HK-2 uptake is a model of renal handling, not a measured whole-body biotin loss in people.
- nutrient_topic
- Biotin research collection; topical membership is not evidence of a direct dietary effect. · Biotin
- organism
- Homo sapiens
- plain_language
- Reduced transporter production is one explanation for the impaired uptake.
- primary_references
- [b7-p21209005] Chronic alcohol exposure negatively impacts the physiological and molecular parameters of the renal biotin reabsorption process. (2011). https://pubmed.ncbi.nlm.nih.gov/21209005/ DOI: 10.1152/ajprenal.00707.2010
- tissue_or_cell_type
- Human HK-2 proximal-tubular epithelial cells
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Biotin: carboxylases, recycling, deficiency and nutrient interactions (2026-09-17) · lines 260–271
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Chronic ethanol exposure in renal HK-2 cells and separate rodents · source_derived_draft · unverified_draft
### b7-kidney-alcohol-transcription Ethanol-exposed HK-2 cells showed reduced activity of the human SLC5A6 regulatory region. Condition category: machinery_impairment nutrient_topic: Biotin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Reduced transporter production is one explanation for the impaired uptake. organism: Homo sapiens tissue_or_cell_type: Human HK-2 proximal-tubular epithelial cells experimental_model: Chronic ethanol exposure in renal HK-2 cells and separate rodents limitations: HK-2 uptake is a model of renal handling, not a measured whole-body biotin loss in people. exposure: Chronic ethanol exposure evidence_span: {"source_cache": "artifacts/biotin-research/21209005.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b42defcb27acffce0c264240e14b0535770f94627ee5a4836b284e4e0971b5a0", "start_char": 0, "end_char": 1797, "text_sha256": "b42defcb27acffce0c264240e14b0535770f94627ee5a4836b284e4e0971b5a0"} [b7-p21209005] Chronic alcohol exposure negatively impacts the physiological and molecular parameters of the renal biotin reabsorption process. (2011). https://pubmed.ncbi.nlm.nih.gov/21209005/ DOI: 10.1152/ajprenal.00707.2010
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.