Component
GOT2 loss in human pancreatic cancer cells
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
GOT2 deletion did not reduce MIA PaCa-2 tumor size in the tested mouse xenografts, despite the synthesis dependency observed in hypoxic culture systems.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Primary full text
- experimental_model
- Human MIA PaCa-2 cells implanted in mice; companion murine and PDX experiments.
- limitations
- This does not prove GOT2 is dispensable in every tumor or that it never contributes to growth.
- nutrient_topic
- L-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Aspartate
- plain_language
- An animal tumor had alternative nutrient routes unavailable in the simplified culture.
- primary_references
- Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35726024/ · DOI 10.1038/s42255-022-00583-z
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
L-Aspartate: redox transfer, nitrogen partitioning and cross-nutrient mechanisms (2026-09-19) · lines 250–256
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human MIA PaCa-2 cells implanted in mice; companion murine and PDX experiments. · source_derived_draft · unverified_draft
## l-aspartate-pdac-got2-invivo-limit An animal tumor had alternative nutrient routes unavailable in the simplified culture. GOT2 deletion did not reduce MIA PaCa-2 tumor size in the tested mouse xenografts, despite the synthesis dependency observed in hypoxic culture systems. Model: Human MIA PaCa-2 cells implanted in mice; companion murine and PDX experiments. Limitations: This does not prove GOT2 is dispensable in every tumor or that it never contributes to growth. Evidence access: Primary full text Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35726024/ · DOI 10.1038/s42255-022-00583-z
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.