Component
Human narcolepsy-associated excessive sleepiness
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Forty-week open-label narcolepsy extensions reported sustained benefit without observed tolerance during that period, with completer selection and later attrition.
Experimental context and source evidence
- evidence_access
- Primary indexed abstract checked; full methods and figures not comprehensively reviewed.
- experimental_contrast
- {"intervention": "Continued modafinil in trial completers", "comparator": "Within-study baseline/follow-up", "endpoint": "Forty-week open-label narcolepsy extensions reported sustained benefit without observed tolerance during that period, with completer selection and later attrition.", "effect_direction": "decrease", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- Human open-label extension studies, forty weeks; no proof that tolerance never occurs.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.
- plain_language
- Forty-week open-label narcolepsy extensions reported sustained benefit without observed tolerance during that period, with completer selection and later attrition.
- primary_references
- Long-term efficacy and safety of modafinil (PROVIGIL((R))) for the treatment of excessive daytime sleepiness associated with narcolepsy. | 2000 | DOI 10.1016/s1389-9457(00)00031-9 | PMID 10828434 | https://pubmed.ncbi.nlm.nih.gov/10828434/
- source_locator
- Reviewed reference lines 164-164; exact primary location described in quoted passage where extracted.
Modafinil: detailed mechanisms of action (reviewed 3 October 2026) · lines 164–164
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Human open-label extension studies, forty weeks; no proof that tolerance never occurs. · Recorded from source · Recorded from source
Reinforcement, tolerance and withdrawal are different endpoints. Forty-week open-label narcolepsy extensions reported sustained benefit without evidence of tolerance during that period, but enrolled completers of prior trials and had subsequent attrition. They cannot demonstrate that tolerance never occurs over years or that all exposure patterns have the same discontinuation effects. [Long-term extension studies](https://pubmed.ncbi.nlm.nih.gov/10828434/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.