Component
Human MTHFD1L short isoform
275-amino-acid alternatively spliced isoform assayed in 2009; distinct from full-length MTHFD1L.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The purified short human MTHFD1L isoform lacked detectable methylene-THF dehydrogenase activity.
Experimental context and source evidence
- experimental_model
- Purified short isoform
- exposure
- Assay conditions described in the linked primary study.
- limitations
- Negative activity result is assay-specific; full-length MTHFD1L has synthetase activity.
- nutrient_topic
- Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. · Folate (vitamin B9)
- organism
- Homo sapiens
- plain_language
- This short isoform cannot be assumed to replace MTHFD2.
- primary_references
- [prasannan-2009] Human mitochondrial C1-tetrahydrofolate synthase: submitochondrial localization of the full-length enzyme and characterization of a short isoform (2009). https://pubmed.ncbi.nlm.nih.gov/18996079/ DOI: 10.1016/j.abb.2008.10.028
- tissue_or_cell_type
- Cell-free
Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 887–897
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified short isoform · source_derived_draft · unverified_draft
### mthfd1l-short-no-dehydrogenase The purified short human MTHFD1L isoform lacked detectable methylene-THF dehydrogenase activity. Condition category: normal nutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: This short isoform cannot be assumed to replace MTHFD2. organism: Homo sapiens tissue_or_cell_type: Cell-free experimental_model: Purified short isoform limitations: Negative activity result is assay-specific; full-length MTHFD1L has synthetase activity. exposure: Assay conditions described in the linked primary study. [prasannan-2009] Human mitochondrial C1-tetrahydrofolate synthase: submitochondrial localization of the full-length enzyme and characterization of a short isoform (2009). https://pubmed.ncbi.nlm.nih.gov/18996079/ DOI: 10.1016/j.abb.2008.10.028
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.