Component
Leg volume in human lymphedema
Leg volume in human lymphedema. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Leg edema declined from 25% to 17% above normal in the 1993 trial (P<0.001).
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/coumarin-research/8377779.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d4b9a301f1334d388b1469a12453ee1af75bcb87f52277dbfac03bcdb045c9ad", "start_char": 0, "end_char": 1907, "text_sha256": "d4b9a301f1334d388b1469a12453ee1af75bcb87f52277dbfac03bcdb045c9ad"}
- experimental_model
- Randomized double-blind placebo-controlled crossover trial
- exposure
- Coumarin 400 mg/day and placebo, six months each
- limitations
- Small older mixed-population trial; positive arm finding was not reproduced in the larger subsequent study.
- nutrient_topic
- Coumarin research collection; topical membership is not evidence of a direct dietary effect. · Coumarin
- organism
- Human
- plain_language
- The same trial reported less leg swelling.
- primary_references
- [coumarin-p8377779] Treatment of lymphedema of the arms and legs with 5,6-benzo-[alpha]-pyrone. (1993). https://pubmed.ncbi.nlm.nih.gov/8377779/ DOI: 10.1056/nejm199310143291604
- tissue_or_cell_type
- 31 postmastectomy arm and 21 other-cause leg lymphedema patients
Coumarin: metabolism, signaling and nutrient connections (2026-09-17) · lines 748–759
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind placebo-controlled crossover trial · source_derived_draft · unverified_draft
### coumarin-leg-positive Leg edema declined from 25% to 17% above normal in the 1993 trial (P<0.001). Condition category: normal nutrient_topic: Coumarin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The same trial reported less leg swelling. organism: Human tissue_or_cell_type: 31 postmastectomy arm and 21 other-cause leg lymphedema patients experimental_model: Randomized double-blind placebo-controlled crossover trial limitations: Small older mixed-population trial; positive arm finding was not reproduced in the larger subsequent study. exposure: Coumarin 400 mg/day and placebo, six months each evidence_span: {"source_cache": "artifacts/coumarin-research/8377779.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d4b9a301f1334d388b1469a12453ee1af75bcb87f52277dbfac03bcdb045c9ad", "start_char": 0, "end_char": 1907, "text_sha256": "d4b9a301f1334d388b1469a12453ee1af75bcb87f52277dbfac03bcdb045c9ad"} [coumarin-p8377779] Treatment of lymphedema of the arms and legs with 5,6-benzo-[alpha]-pyrone. (1993). https://pubmed.ncbi.nlm.nih.gov/8377779/ DOI: 10.1056/nejm199310143291604
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.