Arm volume in human lymphedema: molecular mechanisms & dependencies

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

At six months arm volume changed by +58 mL on coumarin versus +21 mL on placebo (P=0.80).
Coumarin → Arm volume in human lymphedema source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/coumarin-research/9929524.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6d6d4760bdd321dda87f82927c5dfcc7120ed963c101d799473ed53ff4c7764b", "start_char": 0, "end_char": 1579, "text_sha256": "6d6d4760bdd321dda87f82927c5dfcc7120ed963c101d799473ed53ff4c7764b"}
experimental_model
Randomized placebo-controlled crossover replication trial
exposure
Coumarin 200 mg twice daily versus placebo, six months each
limitations
Specific disease population and pharmacological exposure; liver-test incidence cannot be extrapolated to food doses.
nutrient_topic
Coumarin research collection; topical membership is not evidence of a direct dietary effect. · Coumarin
organism
Human
plain_language
The larger trial found no arm-volume benefit.
primary_references
[coumarin-p9929524] Lack of effect of coumarin in women with lymphedema after treatment for breast cancer. (1999). https://pubmed.ncbi.nlm.nih.gov/9929524/ DOI: 10.1056/nejm199902043400503
tissue_or_cell_type
140 women with chronic arm lymphedema after breast cancer treatment
Coumarin: metabolism, signaling and nutrient connections (2026-09-17) · lines 761–772
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized placebo-controlled crossover replication trial · source_derived_draft · unverified_draft
### coumarin-arm-null At six months arm volume changed by +58 mL on coumarin versus +21 mL on placebo (P=0.80). Condition category: normal nutrient_topic: Coumarin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The larger trial found no arm-volume benefit. organism: Human tissue_or_cell_type: 140 women with chronic arm lymphedema after breast cancer treatment experimental_model: Randomized placebo-controlled crossover replication trial limitations: Specific disease population and pharmacological exposure; liver-test incidence cannot be extrapolated to food doses. exposure: Coumarin 200 mg twice daily versus placebo, six months each evidence_span: {"source_cache": "artifacts/coumarin-research/9929524.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6d6d4760bdd321dda87f82927c5dfcc7120ed963c101d799473ed53ff4c7764b", "start_char": 0, "end_char": 1579, "text_sha256": "6d6d4760bdd321dda87f82927c5dfcc7120ed963c101d799473ed53ff4c7764b"} [coumarin-p9929524] Lack of effect of coumarin in women with lymphedema after treatment for breast cancer. (1999). https://pubmed.ncbi.nlm.nih.gov/9929524/ DOI: 10.1056/nejm199902043400503
Complete structured claim and evidence
The 1993 trial reported arm edema declining from 46% to 26% above normal during active treatment (P<0.001).
Coumarin → Arm volume in human lymphedema source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/coumarin-research/8377779.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d4b9a301f1334d388b1469a12453ee1af75bcb87f52277dbfac03bcdb045c9ad", "start_char": 0, "end_char": 1907, "text_sha256": "d4b9a301f1334d388b1469a12453ee1af75bcb87f52277dbfac03bcdb045c9ad"}
experimental_model
Randomized double-blind placebo-controlled crossover trial
exposure
Coumarin 400 mg/day and placebo, six months each
limitations
Small older mixed-population trial; positive arm finding was not reproduced in the larger subsequent study.
nutrient_topic
Coumarin research collection; topical membership is not evidence of a direct dietary effect. · Coumarin
organism
Human
plain_language
This small trial reported less arm swelling.
primary_references
[coumarin-p8377779] Treatment of lymphedema of the arms and legs with 5,6-benzo-[alpha]-pyrone. (1993). https://pubmed.ncbi.nlm.nih.gov/8377779/ DOI: 10.1056/nejm199310143291604
tissue_or_cell_type
31 postmastectomy arm and 21 other-cause leg lymphedema patients
Coumarin: metabolism, signaling and nutrient connections (2026-09-17) · lines 735–746
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind placebo-controlled crossover trial · source_derived_draft · unverified_draft
### coumarin-arm-positive The 1993 trial reported arm edema declining from 46% to 26% above normal during active treatment (P<0.001). Condition category: normal nutrient_topic: Coumarin research collection; topical membership is not evidence of a direct dietary effect. plain_language: This small trial reported less arm swelling. organism: Human tissue_or_cell_type: 31 postmastectomy arm and 21 other-cause leg lymphedema patients experimental_model: Randomized double-blind placebo-controlled crossover trial limitations: Small older mixed-population trial; positive arm finding was not reproduced in the larger subsequent study. exposure: Coumarin 400 mg/day and placebo, six months each evidence_span: {"source_cache": "artifacts/coumarin-research/8377779.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d4b9a301f1334d388b1469a12453ee1af75bcb87f52277dbfac03bcdb045c9ad", "start_char": 0, "end_char": 1907, "text_sha256": "d4b9a301f1334d388b1469a12453ee1af75bcb87f52277dbfac03bcdb045c9ad"} [coumarin-p8377779] Treatment of lymphedema of the arms and legs with 5,6-benzo-[alpha]-pyrone. (1993). https://pubmed.ncbi.nlm.nih.gov/8377779/ DOI: 10.1056/nejm199310143291604
Complete structured claim and evidence

The events it takes part in

A mechanism often involves more than two components. These are the full events, with every participant and its role.

Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

Open hypotheses

Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.

This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

Arm volume in human lymphedema