Component
Glycine carbon incorporation into purines in human LOX IMVI cells
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Carbon-labeled glycine entered purine nucleotides in LOX IMVI cells; positional tracing supported direct glycine incorporation rather than glycine-cleavage-derived one-carbon incorporation in that setting.
Experimental context and source evidence
- evidence_access
- Primary full text
- experimental_model
- Human LOX IMVI and A498 cancer cultures; positional isotope tracing.
- limitations
- This experiment does not measure glycine-cleavage flux in every cell type.
- nutrient_topic
- Glycine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Glycine
- plain_language
- An amino acid can supply part of a DNA/RNA building block directly.
- primary_references
- Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22628656/ · DOI 10.1126/science.1218595
Glycine: supply, one-carbon allocation, receptors and cross-nutrient mechanisms (2026-09-19) · lines 146–152
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human LOX IMVI and A498 cancer cultures; positional isotope tracing. · source_derived_draft · unverified_draft
## glycine-purine-incorporation An amino acid can supply part of a DNA/RNA building block directly. Carbon-labeled glycine entered purine nucleotides in LOX IMVI cells; positional tracing supported direct glycine incorporation rather than glycine-cleavage-derived one-carbon incorporation in that setting. Model: Human LOX IMVI and A498 cancer cultures; positional isotope tracing. Limitations: This experiment does not measure glycine-cleavage flux in every cell type. Evidence access: Primary full text Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22628656/ · DOI 10.1126/science.1218595
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.