Component
Detection of biotin on human histones
Detection of biotin on human histones. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The 2011 study reported natural biotinylation of less than 0.001% of human H3/H4 and argued for rare modification rather than a universal assay artifact.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/biotin-research/21930408.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "51af2341c7be0cb58c57e09784ebb8daabdd98cc93f04be52bb7b04b496e0b91", "start_char": 0, "end_char": 1318, "text_sha256": "51af2341c7be0cb58c57e09784ebb8daabdd98cc93f04be52bb7b04b496e0b91"}
- experimental_model
- Multiple antibody, radiotracer and cell-line comparisons of human histone biotinylation
- exposure
- Assay comparisons responding to artifact criticism
- limitations
- Authors estimated extremely low abundance and proposed HLCS chromatin scaffolding as a working model; nutritional epigenetic benefit was not demonstrated.
- nutrient_topic
- Biotin research collection; topical membership is not evidence of a direct dietary effect. · Biotin
- organism
- Homo sapiens
- plain_language
- Later work defended a very rare mark while questioning whether that tiny amount explains biological effects.
- primary_references
- [b7-p21930408] Biotinylation is a natural, albeit rare, modification of human histones. (2011). https://pubmed.ncbi.nlm.nih.gov/21930408/ DOI: 10.1016/j.ymgme.2011.08.030
- tissue_or_cell_type
- Human histones H3/H4 in cultured cells
Biotin: carboxylases, recycling, deficiency and nutrient interactions (2026-09-17) · lines 1183–1194
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Multiple antibody, radiotracer and cell-line comparisons of human histone biotinylation · source_derived_draft · unverified_draft
### b7-histone-rare-report The 2011 study reported natural biotinylation of less than 0.001% of human H3/H4 and argued for rare modification rather than a universal assay artifact. Condition category: normal nutrient_topic: Biotin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Later work defended a very rare mark while questioning whether that tiny amount explains biological effects. organism: Homo sapiens tissue_or_cell_type: Human histones H3/H4 in cultured cells experimental_model: Multiple antibody, radiotracer and cell-line comparisons of human histone biotinylation limitations: Authors estimated extremely low abundance and proposed HLCS chromatin scaffolding as a working model; nutritional epigenetic benefit was not demonstrated. exposure: Assay comparisons responding to artifact criticism evidence_span: {"source_cache": "artifacts/biotin-research/21930408.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "51af2341c7be0cb58c57e09784ebb8daabdd98cc93f04be52bb7b04b496e0b91", "start_char": 0, "end_char": 1318, "text_sha256": "51af2341c7be0cb58c57e09784ebb8daabdd98cc93f04be52bb7b04b496e0b91"} [b7-p21930408] Biotinylation is a natural, albeit rare, modification of human histones. (2011). https://pubmed.ncbi.nlm.nih.gov/21930408/ DOI: 10.1016/j.ymgme.2011.08.030
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.